Muscle cell outside and inside: the nascent approach of a clinician

Understanding muscle cell in disease and health is an unfinished process. Following the lead of Jaime Alvarez, I have had the opportunity of working on two complementary approaches to this field. One is the study of muscle cell surface molecules. Both synaptic muscle molecules, such as the asymmetri...

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Autor principal: FADIC,RICARDO
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2001
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200018
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spelling oai:scielo:S0716-976020010002000182002-01-02Muscle cell outside and inside: the nascent approach of a clinicianFADIC,RICARDO mitochondrial DNA muscle disease muscular dystrophy proteoglycans Understanding muscle cell in disease and health is an unfinished process. Following the lead of Jaime Alvarez, I have had the opportunity of working on two complementary approaches to this field. One is the study of muscle cell surface molecules. Both synaptic muscle molecules, such as the asymmetric form of acetylcholinesterase, and extrasynaptic molecules, such as the extracellular matrix proteoglycans, are regulated by the motor nerve activity. This illustrates one of Jaime's teachings: cell phenotypes are a dynamic process that reflects the influence of other cells (<A HREF="#0">Alvarez, 2001</A>). Proteoglycans have many functions, including growth factor receptors. Studying them in muscular dystrophy will contribute to the comprehension of the muscle regeneration failure, characteristic of this disease. Muscle cells are highly dependent upon energy production, and the mitochondriae produce most of it. These organelles are unique in having their own genome. Mutations in these genes have recently been recognized as the cause of human disease and originally in muscle pathology. The physiopathology of these diseases is summarized hereinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.34 n.2 20012001-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200018en10.4067/S0716-97602001000200018
institution Scielo Chile
collection Scielo Chile
language English
topic mitochondrial DNA
muscle disease
muscular dystrophy
proteoglycans
spellingShingle mitochondrial DNA
muscle disease
muscular dystrophy
proteoglycans
FADIC,RICARDO
Muscle cell outside and inside: the nascent approach of a clinician
description Understanding muscle cell in disease and health is an unfinished process. Following the lead of Jaime Alvarez, I have had the opportunity of working on two complementary approaches to this field. One is the study of muscle cell surface molecules. Both synaptic muscle molecules, such as the asymmetric form of acetylcholinesterase, and extrasynaptic molecules, such as the extracellular matrix proteoglycans, are regulated by the motor nerve activity. This illustrates one of Jaime's teachings: cell phenotypes are a dynamic process that reflects the influence of other cells (<A HREF="#0">Alvarez, 2001</A>). Proteoglycans have many functions, including growth factor receptors. Studying them in muscular dystrophy will contribute to the comprehension of the muscle regeneration failure, characteristic of this disease. Muscle cells are highly dependent upon energy production, and the mitochondriae produce most of it. These organelles are unique in having their own genome. Mutations in these genes have recently been recognized as the cause of human disease and originally in muscle pathology. The physiopathology of these diseases is summarized here
author FADIC,RICARDO
author_facet FADIC,RICARDO
author_sort FADIC,RICARDO
title Muscle cell outside and inside: the nascent approach of a clinician
title_short Muscle cell outside and inside: the nascent approach of a clinician
title_full Muscle cell outside and inside: the nascent approach of a clinician
title_fullStr Muscle cell outside and inside: the nascent approach of a clinician
title_full_unstemmed Muscle cell outside and inside: the nascent approach of a clinician
title_sort muscle cell outside and inside: the nascent approach of a clinician
publisher Sociedad de Biología de Chile
publishDate 2001
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200018
work_keys_str_mv AT fadicricardo musclecelloutsideandinsidethenascentapproachofaclinician
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