Nitric oxide and carotid body chemoreception

Nitric oxide (NO) has been proposed as an inhibitory modulator of carotid body chemosensory responses to hypoxia. It is believed that NO modulates carotid chemoreception by several mechanisms, which include the control of carotid body vascular tone and oxygen delivery and reduction of the excitabili...

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Autor principal:	ITURRIAGA,RODRIGO
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2001
Materias:	Carotid body chemoreceptor cytochrome oxidase hypoxia nitric oxide oxidative phosphorylation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200019
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spelling	oai:scielo:S0716-976020010002000192002-01-02Nitric oxide and carotid body chemoreceptionITURRIAGA,RODRIGO Carotid body chemoreceptor cytochrome oxidase hypoxia nitric oxide oxidative phosphorylation Nitric oxide (NO) has been proposed as an inhibitory modulator of carotid body chemosensory responses to hypoxia. It is believed that NO modulates carotid chemoreception by several mechanisms, which include the control of carotid body vascular tone and oxygen delivery and reduction of the excitability of chemoreceptor cells and petrosal sensory neurons. In addition to the well-known inhibitory effect, we found that NO has a dual (dose-dependent) effect on carotid chemoreception depending on the oxygen pressure level. During hypoxia, NO is primarily an inhibitory modulator of carotid chemoreception, while in normoxia NO increased the chemosensory activity. This excitatory effect produced by NO is likely mediated by an impairment of mitochondrial electron transport and oxidative phosphorylation, which increases the chemosensory activity. The recent findings that mitochondria contain an isoform of NO synthase, which produces significant amounts of NO for regulating their own respiration, suggest that NO may be important for the regulation of mitochondrial energy metabolism and oxygen sensing in the CB.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.34 n.2 20012001-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200019en10.4067/S0716-97602001000200019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Carotid body chemoreceptor cytochrome oxidase hypoxia nitric oxide oxidative phosphorylation
spellingShingle	Carotid body chemoreceptor cytochrome oxidase hypoxia nitric oxide oxidative phosphorylation ITURRIAGA,RODRIGO Nitric oxide and carotid body chemoreception
description	Nitric oxide (NO) has been proposed as an inhibitory modulator of carotid body chemosensory responses to hypoxia. It is believed that NO modulates carotid chemoreception by several mechanisms, which include the control of carotid body vascular tone and oxygen delivery and reduction of the excitability of chemoreceptor cells and petrosal sensory neurons. In addition to the well-known inhibitory effect, we found that NO has a dual (dose-dependent) effect on carotid chemoreception depending on the oxygen pressure level. During hypoxia, NO is primarily an inhibitory modulator of carotid chemoreception, while in normoxia NO increased the chemosensory activity. This excitatory effect produced by NO is likely mediated by an impairment of mitochondrial electron transport and oxidative phosphorylation, which increases the chemosensory activity. The recent findings that mitochondria contain an isoform of NO synthase, which produces significant amounts of NO for regulating their own respiration, suggest that NO may be important for the regulation of mitochondrial energy metabolism and oxygen sensing in the CB.
author	ITURRIAGA,RODRIGO
author_facet	ITURRIAGA,RODRIGO
author_sort	ITURRIAGA,RODRIGO
title	Nitric oxide and carotid body chemoreception
title_short	Nitric oxide and carotid body chemoreception
title_full	Nitric oxide and carotid body chemoreception
title_fullStr	Nitric oxide and carotid body chemoreception
title_full_unstemmed	Nitric oxide and carotid body chemoreception
title_sort	nitric oxide and carotid body chemoreception
publisher	Sociedad de Biología de Chile
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200019
work_keys_str_mv	AT iturriagarodrigo nitricoxideandcarotidbodychemoreception
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Nitric oxide and carotid body chemoreception

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