Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro exp...

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Autores principales: CUENCA,JIMENA, PÉREZ,CLAUDIO A., AGUIRRE,ADAM J., SCHIATTINO,IRENE, AGUILLÓN,J. CARLOS
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2001
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011
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spelling oai:scielo:S0716-976020010003000112002-06-25Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean populationCUENCA,JIMENAPÉREZ,CLAUDIO A.AGUIRRE,ADAM J.SCHIATTINO,IRENEAGUILLÓN,J. CARLOSSeveral single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.34 n.3-4 20012001-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011en10.4067/S0716-97602001000300011
institution Scielo Chile
collection Scielo Chile
language English
description Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases.
author CUENCA,JIMENA
PÉREZ,CLAUDIO A.
AGUIRRE,ADAM J.
SCHIATTINO,IRENE
AGUILLÓN,J. CARLOS
spellingShingle CUENCA,JIMENA
PÉREZ,CLAUDIO A.
AGUIRRE,ADAM J.
SCHIATTINO,IRENE
AGUILLÓN,J. CARLOS
Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
author_facet CUENCA,JIMENA
PÉREZ,CLAUDIO A.
AGUIRRE,ADAM J.
SCHIATTINO,IRENE
AGUILLÓN,J. CARLOS
author_sort CUENCA,JIMENA
title Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
title_short Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
title_full Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
title_fullStr Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
title_full_unstemmed Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
title_sort genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (tnf): implications of its allelic distribution on susceptibility or resistance to diseases in the chilean population
publisher Sociedad de Biología de Chile
publishDate 2001
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011
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