Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro exp...

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Autores principales: CUENCA,JIMENA, PÉREZ,CLAUDIO A., AGUIRRE,ADAM J., SCHIATTINO,IRENE, AGUILLÓN,J. CARLOS
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2001
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011
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