Glucose transporters: expression, regulation and cancer

Mammalian cells depend on glucose as a major substrate for energy production. Glucose is transported into the cell via facilitative glucose transporters (GLUT) present in all cell types. Many GLUT isoforms have been described and their expression is cell-specific and subject to hormonal and environm...

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Autores principales:	MEDINA,RODOLFO A., OWEN,GARETH I.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	GLUT glucose transporters expression cancer estrogen progesterone cell lines
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000100004
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spelling	oai:scielo:S0716-976020020001000042003-01-28Glucose transporters: expression, regulation and cancerMEDINA,RODOLFO A.OWEN,GARETH I. GLUT glucose transporters expression cancer estrogen progesterone cell lines Mammalian cells depend on glucose as a major substrate for energy production. Glucose is transported into the cell via facilitative glucose transporters (GLUT) present in all cell types. Many GLUT isoforms have been described and their expression is cell-specific and subject to hormonal and environmental control. The kinetic properties and substrate specificities of the different isoforms are specifically suited to the energy requirements of the particular cell types. Due to the ubiquitousness of these transporters, their differential expression is involved in various disease states such as diabetes, ischemia and cancer. The majority of cancers and isolated cancer cell lines over-express the GLUT family members which are present in the respective tissue of origin under non-cancerous conditions. Moreover, due to the requirement of energy to feed uncontrolled proliferation, cancer cells often express GLUTs which under normal conditions would not be present in these tissues. This over-expression is predominantly associated with the likelihood of metastasis and hence poor patient prognosis. This article presents a review of the current literature on the regulation and expression of GLUT family members and has compiled clinical and research data on GLUT expression in human cancers and in isolated human cancer cell lines.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.1 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000100004en10.4067/S0716-97602002000100004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	GLUT glucose transporters expression cancer estrogen progesterone cell lines
spellingShingle	GLUT glucose transporters expression cancer estrogen progesterone cell lines MEDINA,RODOLFO A. OWEN,GARETH I. Glucose transporters: expression, regulation and cancer
description	Mammalian cells depend on glucose as a major substrate for energy production. Glucose is transported into the cell via facilitative glucose transporters (GLUT) present in all cell types. Many GLUT isoforms have been described and their expression is cell-specific and subject to hormonal and environmental control. The kinetic properties and substrate specificities of the different isoforms are specifically suited to the energy requirements of the particular cell types. Due to the ubiquitousness of these transporters, their differential expression is involved in various disease states such as diabetes, ischemia and cancer. The majority of cancers and isolated cancer cell lines over-express the GLUT family members which are present in the respective tissue of origin under non-cancerous conditions. Moreover, due to the requirement of energy to feed uncontrolled proliferation, cancer cells often express GLUTs which under normal conditions would not be present in these tissues. This over-expression is predominantly associated with the likelihood of metastasis and hence poor patient prognosis. This article presents a review of the current literature on the regulation and expression of GLUT family members and has compiled clinical and research data on GLUT expression in human cancers and in isolated human cancer cell lines.
author	MEDINA,RODOLFO A. OWEN,GARETH I.
author_facet	MEDINA,RODOLFO A. OWEN,GARETH I.
author_sort	MEDINA,RODOLFO A.
title	Glucose transporters: expression, regulation and cancer
title_short	Glucose transporters: expression, regulation and cancer
title_full	Glucose transporters: expression, regulation and cancer
title_fullStr	Glucose transporters: expression, regulation and cancer
title_full_unstemmed	Glucose transporters: expression, regulation and cancer
title_sort	glucose transporters: expression, regulation and cancer
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000100004
work_keys_str_mv	AT medinarodolfoa glucosetransportersexpressionregulationandcancer AT owengarethi glucosetransportersexpressionregulationandcancer
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Glucose transporters: expression, regulation and cancer

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