Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons

Protein domains play a fundamental role in the spatial and temporal organization of intracellular signaling systems. While protein phosphorylation has long been known to modify the interactions that underlie this organization, the dynamic cycling of lipids should now be included amongst the posttran...

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Autor principal:	PATTERSON,SEAN I
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	S-palmitoylation synapse growth cone regeneration phosphorylation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200005
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spelling	oai:scielo:S0716-976020020002000052002-12-26Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neuronsPATTERSON,SEAN I S-palmitoylation synapse growth cone regeneration phosphorylation Protein domains play a fundamental role in the spatial and temporal organization of intracellular signaling systems. While protein phosphorylation has long been known to modify the interactions that underlie this organization, the dynamic cycling of lipids should now be included amongst the posttranslational processes determining specificity in signal transduction. The characteristics of this process are reminiscent of the properties of protein and lipid phosphorylation in determining compartmentalization through SH2 or PH domains. Recent studies have confirmed the functional importance of protein S-palmitoylation in the compartmentalization of signaling molecules that support normal physiological function in cell division and apoptosis, and synaptic transmission and neurite outgrowth. In neurons, S-palmitoylation and targeting of proteins to rafts are regulated differentially in development by a number of processes, including some related to synaptogenesis and synaptic plasticity. Alterations in the S-palmitoylation state of proteins substantially affect their cellular function, raising the possibility of new therapeutic targets in cancer and nervous system injury and disease.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200005en10.4067/S0716-97602002000200005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	S-palmitoylation synapse growth cone regeneration phosphorylation
spellingShingle	S-palmitoylation synapse growth cone regeneration phosphorylation PATTERSON,SEAN I Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons
description	Protein domains play a fundamental role in the spatial and temporal organization of intracellular signaling systems. While protein phosphorylation has long been known to modify the interactions that underlie this organization, the dynamic cycling of lipids should now be included amongst the posttranslational processes determining specificity in signal transduction. The characteristics of this process are reminiscent of the properties of protein and lipid phosphorylation in determining compartmentalization through SH2 or PH domains. Recent studies have confirmed the functional importance of protein S-palmitoylation in the compartmentalization of signaling molecules that support normal physiological function in cell division and apoptosis, and synaptic transmission and neurite outgrowth. In neurons, S-palmitoylation and targeting of proteins to rafts are regulated differentially in development by a number of processes, including some related to synaptogenesis and synaptic plasticity. Alterations in the S-palmitoylation state of proteins substantially affect their cellular function, raising the possibility of new therapeutic targets in cancer and nervous system injury and disease.
author	PATTERSON,SEAN I
author_facet	PATTERSON,SEAN I
author_sort	PATTERSON,SEAN I
title	Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons
title_short	Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons
title_full	Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons
title_fullStr	Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons
title_full_unstemmed	Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons
title_sort	posttranslational protein s-palmitoylation and the compartmentalization of signaling molecules in neurons
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200005
work_keys_str_mv	AT pattersonseani posttranslationalproteinspalmitoylationandthecompartmentalizationofsignalingmoleculesinneurons
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Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons

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