Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1

Caveolae are small, flask-shaped invaginations of the plasma membrane present on a large number of mammalian cells. Recent results obtained with knock-out mice for the gene caveolin-1 demonstrate that expression of caveolin-1 protein is essential for caveolae formation in vivo. Caveolae are implicat...

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Autores principales:	BENDER,FLORENT, MONTOYA,MARGARITA, MONARDES,VIRGINIA, LEYTON,LISETTE, QUEST,ANDREW F.G.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	caveolae caveolae-like domains lipid rafts caveolin-1 tumor suppressor colon carcinoma cells microarray analysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200006
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spelling	oai:scielo:S0716-976020020002000062002-12-26Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1BENDER,FLORENTMONTOYA,MARGARITAMONARDES,VIRGINIALEYTON,LISETTEQUEST,ANDREW F.G. caveolae caveolae-like domains lipid rafts caveolin-1 tumor suppressor colon carcinoma cells microarray analysis Caveolae are small, flask-shaped invaginations of the plasma membrane present on a large number of mammalian cells. Recent results obtained with knock-out mice for the gene caveolin-1 demonstrate that expression of caveolin-1 protein is essential for caveolae formation in vivo. Caveolae are implicated in a wide variety of cellular events including transcytosis, cholesterol trafficking and as cellular centers important in coordinating signalling events. Caveolae share this role and the property of detergent insolubility with plasma membrane assemblies rich in glycosphingolipids and cholesterol, often called lipid rafts, but preferably referred to here as caveolae-like membrane domains. Due to such widespread presence and usage in cellular function, caveolae and related domains are implicated in human diseases, including cancer. In particular, the protein caveolin-1 is suggested to function as a tumor suppressor protein. Evidence demonstrating such a role for caveolin-1 in human colon carcinoma cells will be discussed together with data from microarray experiments seeking to identify caveolin-1 target genes responsible for such behavior.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200006en10.4067/S0716-97602002000200006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	caveolae caveolae-like domains lipid rafts caveolin-1 tumor suppressor colon carcinoma cells microarray analysis
spellingShingle	caveolae caveolae-like domains lipid rafts caveolin-1 tumor suppressor colon carcinoma cells microarray analysis BENDER,FLORENT MONTOYA,MARGARITA MONARDES,VIRGINIA LEYTON,LISETTE QUEST,ANDREW F.G. Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1
description	Caveolae are small, flask-shaped invaginations of the plasma membrane present on a large number of mammalian cells. Recent results obtained with knock-out mice for the gene caveolin-1 demonstrate that expression of caveolin-1 protein is essential for caveolae formation in vivo. Caveolae are implicated in a wide variety of cellular events including transcytosis, cholesterol trafficking and as cellular centers important in coordinating signalling events. Caveolae share this role and the property of detergent insolubility with plasma membrane assemblies rich in glycosphingolipids and cholesterol, often called lipid rafts, but preferably referred to here as caveolae-like membrane domains. Due to such widespread presence and usage in cellular function, caveolae and related domains are implicated in human diseases, including cancer. In particular, the protein caveolin-1 is suggested to function as a tumor suppressor protein. Evidence demonstrating such a role for caveolin-1 in human colon carcinoma cells will be discussed together with data from microarray experiments seeking to identify caveolin-1 target genes responsible for such behavior.
author	BENDER,FLORENT MONTOYA,MARGARITA MONARDES,VIRGINIA LEYTON,LISETTE QUEST,ANDREW F.G.
author_facet	BENDER,FLORENT MONTOYA,MARGARITA MONARDES,VIRGINIA LEYTON,LISETTE QUEST,ANDREW F.G.
author_sort	BENDER,FLORENT
title	Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1
title_short	Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1
title_full	Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1
title_fullStr	Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1
title_full_unstemmed	Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1
title_sort	caveolae and caveolae-like membrane domains in cellular signaling and disease: identification of downstream targets for the tumor suppressor protein caveolin-1
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200006
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Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1

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