Calcium signal compartmentalization

Cytosolic calcium signals are produced by suddenly increasing the concentration of free calcium ions (Ca2+). This can occur by opening channels permeable to Ca2+ either in the surface cell membrane or in the membranes of intracellular organelles containing high Ca2+ concentrations. Ca2+ signals can...

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Autor principal:	PETERSEN,OLE H.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	Calcium signals Ca2+ release channels Ca2+ pumps endoplasmic reticulum mitochondria pancreatic acinar cell pancreatitis, secretion apoptosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200008
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spelling	oai:scielo:S0716-976020020002000082002-12-26Calcium signal compartmentalizationPETERSEN,OLE H. Calcium signals Ca2+ release channels Ca2+ pumps endoplasmic reticulum mitochondria pancreatic acinar cell pancreatitis, secretion apoptosis Cytosolic calcium signals are produced by suddenly increasing the concentration of free calcium ions (Ca2+). This can occur by opening channels permeable to Ca2+ either in the surface cell membrane or in the membranes of intracellular organelles containing high Ca2+ concentrations. Ca2+ signals can control several different processes, even in the same cell. In pancreatic acinar cells, for example, Ca2+ signals do not only control the normal secretion of digestive enzymes, but can also activate autodigestion and programmed cell death. Recent technical advances have shown that different patterns of Ca2+ signals can be created, in space and time, which allow specific cellular responses to be elicited. The mechanisms responsible for Ca2+ signal compartmentalization are now largely known and will be described on the basis of recent studies of Ca2+ transport pathways and their regulation in pancreatic acinar cells. It turns out that the Ca2+ handling as well as the structural characteristics of the endoplasmic reticulum (ER) and the mitochondria are of particular importance. Using a variety of Ca2+-sensitive fluorescent probes placed in different sub-cellular compartments in combination with local uncaging of caged Ca2+, many new insights into Ca2+ signal generation, compartmentalization and termination have recently been obtainedinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200008en10.4067/S0716-97602002000200008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Calcium signals Ca2+ release channels Ca2+ pumps endoplasmic reticulum mitochondria pancreatic acinar cell pancreatitis, secretion apoptosis
spellingShingle	Calcium signals Ca2+ release channels Ca2+ pumps endoplasmic reticulum mitochondria pancreatic acinar cell pancreatitis, secretion apoptosis PETERSEN,OLE H. Calcium signal compartmentalization
description	Cytosolic calcium signals are produced by suddenly increasing the concentration of free calcium ions (Ca2+). This can occur by opening channels permeable to Ca2+ either in the surface cell membrane or in the membranes of intracellular organelles containing high Ca2+ concentrations. Ca2+ signals can control several different processes, even in the same cell. In pancreatic acinar cells, for example, Ca2+ signals do not only control the normal secretion of digestive enzymes, but can also activate autodigestion and programmed cell death. Recent technical advances have shown that different patterns of Ca2+ signals can be created, in space and time, which allow specific cellular responses to be elicited. The mechanisms responsible for Ca2+ signal compartmentalization are now largely known and will be described on the basis of recent studies of Ca2+ transport pathways and their regulation in pancreatic acinar cells. It turns out that the Ca2+ handling as well as the structural characteristics of the endoplasmic reticulum (ER) and the mitochondria are of particular importance. Using a variety of Ca2+-sensitive fluorescent probes placed in different sub-cellular compartments in combination with local uncaging of caged Ca2+, many new insights into Ca2+ signal generation, compartmentalization and termination have recently been obtained
author	PETERSEN,OLE H.
author_facet	PETERSEN,OLE H.
author_sort	PETERSEN,OLE H.
title	Calcium signal compartmentalization
title_short	Calcium signal compartmentalization
title_full	Calcium signal compartmentalization
title_fullStr	Calcium signal compartmentalization
title_full_unstemmed	Calcium signal compartmentalization
title_sort	calcium signal compartmentalization
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200008
work_keys_str_mv	AT petersenoleh calciumsignalcompartmentalization
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Calcium signal compartmentalization

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