Ion movements in cell death: from protection to execution

Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby m...

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Autores principales:	FELIPE BARROS,LUIS, CASTRO,JOEL, BITTNER,CARLA X.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	Cell death membrane channels apoptosis necrosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200012
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spelling	oai:scielo:S0716-976020020002000122002-12-26Ion movements in cell death: from protection to executionFELIPE BARROS,LUISCASTRO,JOELBITTNER,CARLA X. Cell death membrane channels apoptosis necrosis Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+]; and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+]and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriersinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200012en10.4067/S0716-97602002000200012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cell death membrane channels apoptosis necrosis
spellingShingle	Cell death membrane channels apoptosis necrosis FELIPE BARROS,LUIS CASTRO,JOEL BITTNER,CARLA X. Ion movements in cell death: from protection to execution
description	Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+]; and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+]and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriers
author	FELIPE BARROS,LUIS CASTRO,JOEL BITTNER,CARLA X.
author_facet	FELIPE BARROS,LUIS CASTRO,JOEL BITTNER,CARLA X.
author_sort	FELIPE BARROS,LUIS
title	Ion movements in cell death: from protection to execution
title_short	Ion movements in cell death: from protection to execution
title_full	Ion movements in cell death: from protection to execution
title_fullStr	Ion movements in cell death: from protection to execution
title_full_unstemmed	Ion movements in cell death: from protection to execution
title_sort	ion movements in cell death: from protection to execution
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200012
work_keys_str_mv	AT felipebarrosluis ionmovementsincelldeathfromprotectiontoexecution AT castrojoel ionmovementsincelldeathfromprotectiontoexecution AT bittnercarlax ionmovementsincelldeathfromprotectiontoexecution
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Ion movements in cell death: from protection to execution

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