Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis

Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycer...

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Autores principales:	WRIGHT,MARCIA M., MCMASTER,CHRISTOPHER R.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	apoptosis diacylglycerol farnesol phorbol ester protein kinase C
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200014
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spelling	oai:scielo:S0716-976020020002000142002-12-26Phospholipid synthesis, diacylglycerol compartmentation, and apoptosisWRIGHT,MARCIA M.MCMASTER,CHRISTOPHER R. apoptosis diacylglycerol farnesol phorbol ester protein kinase C Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycerol is a lipid second messenger that regulates cell growth and apoptosis and is produced during signal transduction by hydrolysis of membrane phospholipids. Protein kinase Cs are a family of diacylglycerol responsive enzymes that are recruited to cellular membranes as a consequence of diacylglycerol production where they phosphorylate specific target proteins responsible for regulating cell growth. In this review, we will first summarize our current understanding of the role of specific proteins kinase C isoforms in the induction of cell growth/apoptosis. Subsequently, we will discuss how insights gained in lipid-mediated regulation of protein kinase Cs promotes our understanding of the role specific family members play in regulating cell growth. Finally, other diacylglycerol binding proteins involved in regulating apoptosis will be discussedinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200014en10.4067/S0716-97602002000200014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	apoptosis diacylglycerol farnesol phorbol ester protein kinase C
spellingShingle	apoptosis diacylglycerol farnesol phorbol ester protein kinase C WRIGHT,MARCIA M. MCMASTER,CHRISTOPHER R. Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
description	Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycerol is a lipid second messenger that regulates cell growth and apoptosis and is produced during signal transduction by hydrolysis of membrane phospholipids. Protein kinase Cs are a family of diacylglycerol responsive enzymes that are recruited to cellular membranes as a consequence of diacylglycerol production where they phosphorylate specific target proteins responsible for regulating cell growth. In this review, we will first summarize our current understanding of the role of specific proteins kinase C isoforms in the induction of cell growth/apoptosis. Subsequently, we will discuss how insights gained in lipid-mediated regulation of protein kinase Cs promotes our understanding of the role specific family members play in regulating cell growth. Finally, other diacylglycerol binding proteins involved in regulating apoptosis will be discussed
author	WRIGHT,MARCIA M. MCMASTER,CHRISTOPHER R.
author_facet	WRIGHT,MARCIA M. MCMASTER,CHRISTOPHER R.
author_sort	WRIGHT,MARCIA M.
title	Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
title_short	Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
title_full	Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
title_fullStr	Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
title_full_unstemmed	Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
title_sort	phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200014
work_keys_str_mv	AT wrightmarciam phospholipidsynthesisdiacylglycerolcompartmentationandapoptosis AT mcmasterchristopherr phospholipidsynthesisdiacylglycerolcompartmentationandapoptosis
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Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis

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