Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion

Integrins and cadherins are transmembrane adhesion receptors that are necessary for cells to interact with the extracellular matrix or adjacent cells, respectively. Integrins and cadherins initiate signaling pathways that modulate the activity of Rho family GTPases. The Rho proteins Cdc42, Rac1, and...

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Autores principales:	ARTHUR,WILLIAM T., NOREN,NICOLE K., BURRIDGE,KEITH
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	Integrins Cadherins Adhesion Rho Rac Cdc42
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200016
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spelling	oai:scielo:S0716-976020020002000162002-12-26Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix AdhesionARTHUR,WILLIAM T.NOREN,NICOLE K.BURRIDGE,KEITH Integrins Cadherins Adhesion Rho Rac Cdc42 Integrins and cadherins are transmembrane adhesion receptors that are necessary for cells to interact with the extracellular matrix or adjacent cells, respectively. Integrins and cadherins initiate signaling pathways that modulate the activity of Rho family GTPases. The Rho proteins Cdc42, Rac1, and RhoA regulate the actin cytoskeleton. Cdc42 and Rac1 are primarily involved in the formation of protrusive structures, while RhoA generates myosin-based contractility. Here we examine the differential regulation of RhoA, Cdc42, and Rac1 by integrin and cadherin signaling. Integrin and cadherin signaling leads to a decrease in RhoA activity and activation of Cdc42 and Rac1. When the normal RhoA suppression is antagonized or RhoA signaling is increased, cells exhibited impaired spreading on the matrix protein fibronectin and decreased cell-cell adhesion. Spreading on fibronectin and the formation of cell-cell adhesions is decreased in cells expressing dominant negative forms of Cdc42 or Rac1. These data demonstrate that integrins and cadherins regulate Rho proteins in a comparable manner and lead us to speculate that these changes in Rho protein activity participate in a feedback mechanism that promotes further cell-matrix or cell-cell interaction, respectivelyinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200016en10.4067/S0716-97602002000200016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Integrins Cadherins Adhesion Rho Rac Cdc42
spellingShingle	Integrins Cadherins Adhesion Rho Rac Cdc42 ARTHUR,WILLIAM T. NOREN,NICOLE K. BURRIDGE,KEITH Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
description	Integrins and cadherins are transmembrane adhesion receptors that are necessary for cells to interact with the extracellular matrix or adjacent cells, respectively. Integrins and cadherins initiate signaling pathways that modulate the activity of Rho family GTPases. The Rho proteins Cdc42, Rac1, and RhoA regulate the actin cytoskeleton. Cdc42 and Rac1 are primarily involved in the formation of protrusive structures, while RhoA generates myosin-based contractility. Here we examine the differential regulation of RhoA, Cdc42, and Rac1 by integrin and cadherin signaling. Integrin and cadherin signaling leads to a decrease in RhoA activity and activation of Cdc42 and Rac1. When the normal RhoA suppression is antagonized or RhoA signaling is increased, cells exhibited impaired spreading on the matrix protein fibronectin and decreased cell-cell adhesion. Spreading on fibronectin and the formation of cell-cell adhesions is decreased in cells expressing dominant negative forms of Cdc42 or Rac1. These data demonstrate that integrins and cadherins regulate Rho proteins in a comparable manner and lead us to speculate that these changes in Rho protein activity participate in a feedback mechanism that promotes further cell-matrix or cell-cell interaction, respectively
author	ARTHUR,WILLIAM T. NOREN,NICOLE K. BURRIDGE,KEITH
author_facet	ARTHUR,WILLIAM T. NOREN,NICOLE K. BURRIDGE,KEITH
author_sort	ARTHUR,WILLIAM T.
title	Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
title_short	Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
title_full	Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
title_fullStr	Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
title_full_unstemmed	Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
title_sort	regulation of rho family gtpases by cell-cell and cell-matrix adhesion
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200016
work_keys_str_mv	AT arthurwilliamt regulationofrhofamilygtpasesbycellcellandcellmatrixadhesion AT norennicolek regulationofrhofamilygtpasesbycellcellandcellmatrixadhesion AT burridgekeith regulationofrhofamilygtpasesbycellcellandcellmatrixadhesion
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Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion

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