Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors

The ADP-ribosylation factor family of small GTP-binding proteins are implicated in the regulation of vesicular transport and control of cytoskeletal and cell adhesion events. The phosphoinositide 3-kinase, phosphoinositide 4-P 5-kinase and phospholipase D signaling pathways are major regulators of A...

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Autores principales:	HAWADLE,MUHAMED A., FOLARIN,NAJEEM, MARTIN,ROSEMARY, JACKSON,TREVOR R.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	ADP-ribosylation factor Cytohesin; Centaurin GTPase Activating Protein Guanine nucleotide Exchange Factor Phosphoinositide
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200017
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spelling	oai:scielo:S0716-976020020002000172002-12-26Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation FactorsHAWADLE,MUHAMED A.FOLARIN,NAJEEMMARTIN,ROSEMARYJACKSON,TREVOR R. ADP-ribosylation factor Cytohesin; Centaurin GTPase Activating Protein Guanine nucleotide Exchange Factor Phosphoinositide The ADP-ribosylation factor family of small GTP-binding proteins are implicated in the regulation of vesicular transport and control of cytoskeletal and cell adhesion events. The phosphoinositide 3-kinase, phosphoinositide 4-P 5-kinase and phospholipase D signaling pathways are major regulators of ARF signaling cascades. Two families of ARF regulatory molecules, the cytohesin ARF-Guanine nucleotide Exchange Factors and the centaurin GTPase-Activating Proteins provide key targets for the action of these lipid signals. A critical feature of the regulation of ARF signaling is coordinated recruitment of exchange factors, ARFs and GAPs to appropriate subcellular locations. These complexes drive repetitive cycles of ARF activation and membrane association that underlie the processes of cell movement as well as endosomal uptake and intracellular redistribution of signaling molecules. Cytohesins and centaurins bind specifically to a variety of other signaling proteins and these interactions may provide routes for regulated recruitment to the sites of ARF activation. Through their ability to control endosomal trafficking/recycling of these supramolecular signaling complexes ARF and phospholipid signaling pathways may have consequences that reach as far as the regulation of gene transcription and control of cell fateinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200017en10.4067/S0716-97602002000200017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	ADP-ribosylation factor Cytohesin; Centaurin GTPase Activating Protein Guanine nucleotide Exchange Factor Phosphoinositide
spellingShingle	ADP-ribosylation factor Cytohesin; Centaurin GTPase Activating Protein Guanine nucleotide Exchange Factor Phosphoinositide HAWADLE,MUHAMED A. FOLARIN,NAJEEM MARTIN,ROSEMARY JACKSON,TREVOR R. Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors
description	The ADP-ribosylation factor family of small GTP-binding proteins are implicated in the regulation of vesicular transport and control of cytoskeletal and cell adhesion events. The phosphoinositide 3-kinase, phosphoinositide 4-P 5-kinase and phospholipase D signaling pathways are major regulators of ARF signaling cascades. Two families of ARF regulatory molecules, the cytohesin ARF-Guanine nucleotide Exchange Factors and the centaurin GTPase-Activating Proteins provide key targets for the action of these lipid signals. A critical feature of the regulation of ARF signaling is coordinated recruitment of exchange factors, ARFs and GAPs to appropriate subcellular locations. These complexes drive repetitive cycles of ARF activation and membrane association that underlie the processes of cell movement as well as endosomal uptake and intracellular redistribution of signaling molecules. Cytohesins and centaurins bind specifically to a variety of other signaling proteins and these interactions may provide routes for regulated recruitment to the sites of ARF activation. Through their ability to control endosomal trafficking/recycling of these supramolecular signaling complexes ARF and phospholipid signaling pathways may have consequences that reach as far as the regulation of gene transcription and control of cell fate
author	HAWADLE,MUHAMED A. FOLARIN,NAJEEM MARTIN,ROSEMARY JACKSON,TREVOR R.
author_facet	HAWADLE,MUHAMED A. FOLARIN,NAJEEM MARTIN,ROSEMARY JACKSON,TREVOR R.
author_sort	HAWADLE,MUHAMED A.
title	Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors
title_short	Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors
title_full	Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors
title_fullStr	Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors
title_full_unstemmed	Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors
title_sort	cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: regulation by phosphoinositides and adp-ribosylation factors
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200017
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Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors

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