Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells

The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different si...

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Autores principales:	AYBAR,MANUEL J., GLAVIC,ALVARO, MAYOR,ROBERTO
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	neural crest induction BMPs Wnts FGF retinoic acid Notch, delta
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018
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spelling	oai:scielo:S0716-976020020002000182002-12-26Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cellsAYBAR,MANUEL J.GLAVIC,ALVAROMAYOR,ROBERTO neural crest induction BMPs Wnts FGF retinoic acid Notch, delta The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. First, a gradient of bone morphogenic proteins (BMPs) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of BMP activity. Thus, the neural folds are induced at a precise threshold concentration of BMP, but this neural fold has an anterior character. In a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, Wnts and retinoic acid. Finally, the induced cells interact to complete neural crest induction by a process that requires Notch/Delta signaling. Once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiationinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018en10.4067/S0716-97602002000200018
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	neural crest induction BMPs Wnts FGF retinoic acid Notch, delta
spellingShingle	neural crest induction BMPs Wnts FGF retinoic acid Notch, delta AYBAR,MANUEL J. GLAVIC,ALVARO MAYOR,ROBERTO Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
description	The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. First, a gradient of bone morphogenic proteins (BMPs) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of BMP activity. Thus, the neural folds are induced at a precise threshold concentration of BMP, but this neural fold has an anterior character. In a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, Wnts and retinoic acid. Finally, the induced cells interact to complete neural crest induction by a process that requires Notch/Delta signaling. Once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiation
author	AYBAR,MANUEL J. GLAVIC,ALVARO MAYOR,ROBERTO
author_facet	AYBAR,MANUEL J. GLAVIC,ALVARO MAYOR,ROBERTO
author_sort	AYBAR,MANUEL J.
title	Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_short	Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_full	Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_fullStr	Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_full_unstemmed	Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_sort	extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018
work_keys_str_mv	AT aybarmanuelj extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells AT glavicalvaro extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells AT mayorroberto extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells
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Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells

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