Modulation of nuclear receptor dependent transcription

Nuclear receptors comprise a family of transcription factors that regulate gene expression in a ligand dependent manner. They can activate or repress target genes by binding directly to DNA response elements as homo- or hetero-dimers or by binding to other classes of DNA-bound transcription factors....

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: HART,STEPHEN M
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2002
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200021
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0716-97602002000200021
record_format dspace
spelling oai:scielo:S0716-976020020002000212002-12-26Modulation of nuclear receptor dependent transcriptionHART,STEPHEN MNuclear receptors comprise a family of transcription factors that regulate gene expression in a ligand dependent manner. They can activate or repress target genes by binding directly to DNA response elements as homo- or hetero-dimers or by binding to other classes of DNA-bound transcription factors. These activities have been linked to the formation of complexes with molecules that appear to serve as coactivators or corepressors, causing local modification of chromatin structure in order to regulate expression of their target genes. Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukaemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-a (ERa) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor a (RARa) in acute promyelocytic leukaemiainfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200021en10.4067/S0716-97602002000200021
institution Scielo Chile
collection Scielo Chile
language English
description Nuclear receptors comprise a family of transcription factors that regulate gene expression in a ligand dependent manner. They can activate or repress target genes by binding directly to DNA response elements as homo- or hetero-dimers or by binding to other classes of DNA-bound transcription factors. These activities have been linked to the formation of complexes with molecules that appear to serve as coactivators or corepressors, causing local modification of chromatin structure in order to regulate expression of their target genes. Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukaemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-a (ERa) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor a (RARa) in acute promyelocytic leukaemia
author HART,STEPHEN M
spellingShingle HART,STEPHEN M
Modulation of nuclear receptor dependent transcription
author_facet HART,STEPHEN M
author_sort HART,STEPHEN M
title Modulation of nuclear receptor dependent transcription
title_short Modulation of nuclear receptor dependent transcription
title_full Modulation of nuclear receptor dependent transcription
title_fullStr Modulation of nuclear receptor dependent transcription
title_full_unstemmed Modulation of nuclear receptor dependent transcription
title_sort modulation of nuclear receptor dependent transcription
publisher Sociedad de Biología de Chile
publishDate 2002
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200021
work_keys_str_mv AT hartstephenm modulationofnuclearreceptordependenttranscription
_version_ 1718441343026462720