Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse

In this study, we showed the effect of the betamethasone, sulindac and quinacrine alone or combined, on the inflammatory angiogenesis promoted by polyurethane sponge on mice. The main finding reported here is that the formation of new blood vessels was strongly inhibited by low concentration of beta...

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Autores principales:	ILLANES,JULIO, DABANCENS,ALFREDO, ACUÑA,OLGA, FUENZALIDA,MARCELA, GUERRERO,ANIBAL, LOPEZ,CLAUDIA, LEMUS,DAVID
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2002
Materias:	angiogenesis antiangiogenesis betamethasone sulindac quinacrine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300008
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spelling	oai:scielo:S0716-976020020003000082003-11-26Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouseILLANES,JULIODABANCENS,ALFREDOACUÑA,OLGAFUENZALIDA,MARCELAGUERRERO,ANIBALLOPEZ,CLAUDIALEMUS,DAVID angiogenesis antiangiogenesis betamethasone sulindac quinacrine In this study, we showed the effect of the betamethasone, sulindac and quinacrine alone or combined, on the inflammatory angiogenesis promoted by polyurethane sponge on mice. The main finding reported here is that the formation of new blood vessels was strongly inhibited by low concentration of betamethasone, sulindac or quinacrine, whether alone or in combination. It is known that steroidal anti-inflammatory drugs inhibit the enzymes required for the production of prostaglandins through a nuclear glucocorticoid receptor (GR) mediated mechanism. This mechanism may occur in endothelial cells as well. Considering that activity of cyclo-oxigenases 1 and 2 is inhibited by sulindac, and that these enzymes are located in the stromal tissue, we propose that the anti-angiogenic effect of these agents may occur via inhibition of both COX isoforms. On the other hand, quinacrine inhibited PLA2 activity, and we propose here that the anti-angiogenic effect occurs via inhibition of the enzyme PLA2. The potentiated effect of the association of betamethasone, sulindac and quinacrine may have some therapeutic benefit in the control of pathological angiogenesis. Further studies are required to validate these propositionsinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.3-4 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300008en10.4067/S0716-97602002000300008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	angiogenesis antiangiogenesis betamethasone sulindac quinacrine
spellingShingle	angiogenesis antiangiogenesis betamethasone sulindac quinacrine ILLANES,JULIO DABANCENS,ALFREDO ACUÑA,OLGA FUENZALIDA,MARCELA GUERRERO,ANIBAL LOPEZ,CLAUDIA LEMUS,DAVID Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
description	In this study, we showed the effect of the betamethasone, sulindac and quinacrine alone or combined, on the inflammatory angiogenesis promoted by polyurethane sponge on mice. The main finding reported here is that the formation of new blood vessels was strongly inhibited by low concentration of betamethasone, sulindac or quinacrine, whether alone or in combination. It is known that steroidal anti-inflammatory drugs inhibit the enzymes required for the production of prostaglandins through a nuclear glucocorticoid receptor (GR) mediated mechanism. This mechanism may occur in endothelial cells as well. Considering that activity of cyclo-oxigenases 1 and 2 is inhibited by sulindac, and that these enzymes are located in the stromal tissue, we propose that the anti-angiogenic effect of these agents may occur via inhibition of both COX isoforms. On the other hand, quinacrine inhibited PLA2 activity, and we propose here that the anti-angiogenic effect occurs via inhibition of the enzyme PLA2. The potentiated effect of the association of betamethasone, sulindac and quinacrine may have some therapeutic benefit in the control of pathological angiogenesis. Further studies are required to validate these propositions
author	ILLANES,JULIO DABANCENS,ALFREDO ACUÑA,OLGA FUENZALIDA,MARCELA GUERRERO,ANIBAL LOPEZ,CLAUDIA LEMUS,DAVID
author_facet	ILLANES,JULIO DABANCENS,ALFREDO ACUÑA,OLGA FUENZALIDA,MARCELA GUERRERO,ANIBAL LOPEZ,CLAUDIA LEMUS,DAVID
author_sort	ILLANES,JULIO
title	Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
title_short	Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
title_full	Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
title_fullStr	Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
title_full_unstemmed	Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
title_sort	effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
publisher	Sociedad de Biología de Chile
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300008
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Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse

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