Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
In this study, we showed the effect of the betamethasone, sulindac and quinacrine alone or combined, on the inflammatory angiogenesis promoted by polyurethane sponge on mice. The main finding reported here is that the formation of new blood vessels was strongly inhibited by low concentration of beta...
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Sociedad de Biología de Chile
2002
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oai:scielo:S0716-976020020003000082003-11-26Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouseILLANES,JULIODABANCENS,ALFREDOACUÑA,OLGAFUENZALIDA,MARCELAGUERRERO,ANIBALLOPEZ,CLAUDIALEMUS,DAVID angiogenesis antiangiogenesis betamethasone sulindac quinacrine In this study, we showed the effect of the betamethasone, sulindac and quinacrine alone or combined, on the inflammatory angiogenesis promoted by polyurethane sponge on mice. The main finding reported here is that the formation of new blood vessels was strongly inhibited by low concentration of betamethasone, sulindac or quinacrine, whether alone or in combination. It is known that steroidal anti-inflammatory drugs inhibit the enzymes required for the production of prostaglandins through a nuclear glucocorticoid receptor (GR) mediated mechanism. This mechanism may occur in endothelial cells as well. Considering that activity of cyclo-oxigenases 1 and 2 is inhibited by sulindac, and that these enzymes are located in the stromal tissue, we propose that the anti-angiogenic effect of these agents may occur via inhibition of both COX isoforms. On the other hand, quinacrine inhibited PLA2 activity, and we propose here that the anti-angiogenic effect occurs via inhibition of the enzyme PLA2. The potentiated effect of the association of betamethasone, sulindac and quinacrine may have some therapeutic benefit in the control of pathological angiogenesis. Further studies are required to validate these propositionsinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.35 n.3-4 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300008en10.4067/S0716-97602002000300008 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
angiogenesis antiangiogenesis betamethasone sulindac quinacrine |
| spellingShingle |
angiogenesis antiangiogenesis betamethasone sulindac quinacrine ILLANES,JULIO DABANCENS,ALFREDO ACUÑA,OLGA FUENZALIDA,MARCELA GUERRERO,ANIBAL LOPEZ,CLAUDIA LEMUS,DAVID Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse |
| description |
In this study, we showed the effect of the betamethasone, sulindac and quinacrine alone or combined, on the inflammatory angiogenesis promoted by polyurethane sponge on mice. The main finding reported here is that the formation of new blood vessels was strongly inhibited by low concentration of betamethasone, sulindac or quinacrine, whether alone or in combination. It is known that steroidal anti-inflammatory drugs inhibit the enzymes required for the production of prostaglandins through a nuclear glucocorticoid receptor (GR) mediated mechanism. This mechanism may occur in endothelial cells as well. Considering that activity of cyclo-oxigenases 1 and 2 is inhibited by sulindac, and that these enzymes are located in the stromal tissue, we propose that the anti-angiogenic effect of these agents may occur via inhibition of both COX isoforms. On the other hand, quinacrine inhibited PLA2 activity, and we propose here that the anti-angiogenic effect occurs via inhibition of the enzyme PLA2. The potentiated effect of the association of betamethasone, sulindac and quinacrine may have some therapeutic benefit in the control of pathological angiogenesis. Further studies are required to validate these propositions |
| author |
ILLANES,JULIO DABANCENS,ALFREDO ACUÑA,OLGA FUENZALIDA,MARCELA GUERRERO,ANIBAL LOPEZ,CLAUDIA LEMUS,DAVID |
| author_facet |
ILLANES,JULIO DABANCENS,ALFREDO ACUÑA,OLGA FUENZALIDA,MARCELA GUERRERO,ANIBAL LOPEZ,CLAUDIA LEMUS,DAVID |
| author_sort |
ILLANES,JULIO |
| title |
Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse |
| title_short |
Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse |
| title_full |
Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse |
| title_fullStr |
Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse |
| title_full_unstemmed |
Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse |
| title_sort |
effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2002 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300008 |
| work_keys_str_mv |
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| _version_ |
1718441345243152384 |