Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis

We report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M, and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7%. These genome segments code for a nucleocapsid protein of 428 am...

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Autores principales:	TISCHLER,NICOLE D, FERNÁNDEZ,JORGE, MÜLLER,ILSE, MARTÍNEZ,RODRIGO, GALENO,HÉCTOR, VILLAGRA,ELIECER, MORA,JUDITH, RAMÍREZ,EUGENIO, ROSEMBLATT,MARIO, VALENZUELA,PABLO D.T.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2003
Materias:	Hantavirus genome sequence RNA polymerase human isolate
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200010
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spelling	oai:scielo:S0716-976020030002000102003-11-19Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysisTISCHLER,NICOLE DFERNÁNDEZ,JORGEMÜLLER,ILSEMARTÍNEZ,RODRIGOGALENO,HÉCTORVILLAGRA,ELIECERMORA,JUDITHRAMÍREZ,EUGENIOROSEMBLATT,MARIOVALENZUELA,PABLO D.T. Hantavirus genome sequence RNA polymerase human isolate We report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M, and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7%. These genome segments code for a nucleocapsid protein of 428 amino acids, a glycoprotein precursor protein of 1,138 amino acids and a RNA-dependent RNA polymerase of 2,152 amino acids. In addition, the genome also has other ORFs coding for putative proteins of 34 to 103 amino acids. The encoded proteins have greater than 98% overall similarity with the proteins of Andes virus isolates AH-1 and Chile R123. Among other sequenced Hantavirus, CHI-7913 is more closely related to Sin Nombre virus, with an overall protein similarity of 92%. The characteristics of the encoded proteins of this isolate, such as hydrophobic domains, glycosylation sites, and conserved amino acid motifs shared with other Hantavirus and other members of the Bunyaviridae family, are identified and discussed.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.36 n.2 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200010en10.4067/S0716-97602003000200010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hantavirus genome sequence RNA polymerase human isolate
spellingShingle	Hantavirus genome sequence RNA polymerase human isolate TISCHLER,NICOLE D FERNÁNDEZ,JORGE MÜLLER,ILSE MARTÍNEZ,RODRIGO GALENO,HÉCTOR VILLAGRA,ELIECER MORA,JUDITH RAMÍREZ,EUGENIO ROSEMBLATT,MARIO VALENZUELA,PABLO D.T. Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
description	We report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M, and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7%. These genome segments code for a nucleocapsid protein of 428 amino acids, a glycoprotein precursor protein of 1,138 amino acids and a RNA-dependent RNA polymerase of 2,152 amino acids. In addition, the genome also has other ORFs coding for putative proteins of 34 to 103 amino acids. The encoded proteins have greater than 98% overall similarity with the proteins of Andes virus isolates AH-1 and Chile R123. Among other sequenced Hantavirus, CHI-7913 is more closely related to Sin Nombre virus, with an overall protein similarity of 92%. The characteristics of the encoded proteins of this isolate, such as hydrophobic domains, glycosylation sites, and conserved amino acid motifs shared with other Hantavirus and other members of the Bunyaviridae family, are identified and discussed.
author	TISCHLER,NICOLE D FERNÁNDEZ,JORGE MÜLLER,ILSE MARTÍNEZ,RODRIGO GALENO,HÉCTOR VILLAGRA,ELIECER MORA,JUDITH RAMÍREZ,EUGENIO ROSEMBLATT,MARIO VALENZUELA,PABLO D.T.
author_facet	TISCHLER,NICOLE D FERNÁNDEZ,JORGE MÜLLER,ILSE MARTÍNEZ,RODRIGO GALENO,HÉCTOR VILLAGRA,ELIECER MORA,JUDITH RAMÍREZ,EUGENIO ROSEMBLATT,MARIO VALENZUELA,PABLO D.T.
author_sort	TISCHLER,NICOLE D
title	Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
title_short	Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
title_full	Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
title_fullStr	Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
title_full_unstemmed	Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
title_sort	complete sequence of the genome of the human isolate of andes virus chi-7913: comparative sequence and protein structure analysis
publisher	Sociedad de Biología de Chile
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200010
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Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis

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