Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo

Angiogenesis, the development of new blood vessels from the existing vascular network, may result as a consequence of the increase or decrease of proangiogenic or antiangiogenic factors, respectively. The tumor itself could up-regulate the production of angiogenic factors. Recently, we established t...

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Autores principales:	ZÚÑIGA,JORGE, FUENZALIDA,MARCELA, GUERRERO,ANÍBAL, ILLANES,JULIO, DABANCENS,ALFREDO, DÍAZ,EUGENIA, LEMUS,DAVID
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2003
Materias:	Angiogenesis Antiangiogenesis Tumor betamethasone ketoprofen
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200013
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spelling	oai:scielo:S0716-976020030002000132003-11-19Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick EmbryoZÚÑIGA,JORGEFUENZALIDA,MARCELAGUERRERO,ANÍBALILLANES,JULIODABANCENS,ALFREDODÍAZ,EUGENIALEMUS,DAVID Angiogenesis Antiangiogenesis Tumor betamethasone ketoprofen Angiogenesis, the development of new blood vessels from the existing vascular network, may result as a consequence of the increase or decrease of proangiogenic or antiangiogenic factors, respectively. The tumor itself could up-regulate the production of angiogenic factors. Recently, we established that the steroidal drug betamethasone in low concentration inhibit the neovascularization promoted by TA3 Ts on CAM of chick embryos. We describe here the effects of the non-steroidal drug ketoprofen, alone or in association with betamethasone, on the angiogenesis promoted by TA3 Ts on CAM. The main finding reported here is that the formation of new blood vessels is strongly inhibited by low concentrations of ketoprofen. The association of both drugs produced a synergistic effect, significantly decreasing tumoral supernatant angiogenesis. It is known that steroidal anti-inflammatory drugs inhibit the enzymes required for the production of prostaglandins through a nuclear GR mediated mechanism. This may operate as a general mechanism in endothelial cells as well. Considering that the induction of COX 1 and COX2 are inhibited by ketoprofen, and that these enzymes are located in the stromal compartment of the CAM, we propose that its antiangiogenic effect may occur via inhibition of the two COX isoforms. In fact, we found that ketoprofen induced apoptosis in both the stromal fibroblast and endotelial cells. The potentiated effect of the combination of betamethasone and ketoprofen may have some therapeutic projections in the control of pathological angiogenesisinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.36 n.2 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200013en10.4067/S0716-97602003000200013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Angiogenesis Antiangiogenesis Tumor betamethasone ketoprofen
spellingShingle	Angiogenesis Antiangiogenesis Tumor betamethasone ketoprofen ZÚÑIGA,JORGE FUENZALIDA,MARCELA GUERRERO,ANÍBAL ILLANES,JULIO DABANCENS,ALFREDO DÍAZ,EUGENIA LEMUS,DAVID Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo
description	Angiogenesis, the development of new blood vessels from the existing vascular network, may result as a consequence of the increase or decrease of proangiogenic or antiangiogenic factors, respectively. The tumor itself could up-regulate the production of angiogenic factors. Recently, we established that the steroidal drug betamethasone in low concentration inhibit the neovascularization promoted by TA3 Ts on CAM of chick embryos. We describe here the effects of the non-steroidal drug ketoprofen, alone or in association with betamethasone, on the angiogenesis promoted by TA3 Ts on CAM. The main finding reported here is that the formation of new blood vessels is strongly inhibited by low concentrations of ketoprofen. The association of both drugs produced a synergistic effect, significantly decreasing tumoral supernatant angiogenesis. It is known that steroidal anti-inflammatory drugs inhibit the enzymes required for the production of prostaglandins through a nuclear GR mediated mechanism. This may operate as a general mechanism in endothelial cells as well. Considering that the induction of COX 1 and COX2 are inhibited by ketoprofen, and that these enzymes are located in the stromal compartment of the CAM, we propose that its antiangiogenic effect may occur via inhibition of the two COX isoforms. In fact, we found that ketoprofen induced apoptosis in both the stromal fibroblast and endotelial cells. The potentiated effect of the combination of betamethasone and ketoprofen may have some therapeutic projections in the control of pathological angiogenesis
author	ZÚÑIGA,JORGE FUENZALIDA,MARCELA GUERRERO,ANÍBAL ILLANES,JULIO DABANCENS,ALFREDO DÍAZ,EUGENIA LEMUS,DAVID
author_facet	ZÚÑIGA,JORGE FUENZALIDA,MARCELA GUERRERO,ANÍBAL ILLANES,JULIO DABANCENS,ALFREDO DÍAZ,EUGENIA LEMUS,DAVID
author_sort	ZÚÑIGA,JORGE
title	Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo
title_short	Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo
title_full	Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo
title_fullStr	Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo
title_full_unstemmed	Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo
title_sort	effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral ta3 supernatant on cam from chick embryo
publisher	Sociedad de Biología de Chile
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200013
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Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo

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