Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice

Treatment of tumor-bearing mice with LD12.5 values of iodoacetate; IAA (1.84 mg/100g b.w.) and/or dimethylsulphoxide; DMSO (350 mg/ 100g b.w.) significantly increased the cumulative mean survival time and percentage of survivors and reduced the mean tumor weight, compared to tumor-bearing controls,...

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Autores principales:	FAHIM,FAWZIA A , ESMAT,AMR Y, MADY,ESSAM A, IBRAHIM,EMAD K
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2003
Materias:	antioxidant enzymes carbohydrate metabolism dimethylsulphoxide iodoacetate solid Ehrlich carcinoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200015
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spelling	oai:scielo:S0716-976020030002000152003-11-19Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in MiceFAHIM,FAWZIA A ESMAT,AMR YMADY,ESSAM AIBRAHIM,EMAD K antioxidant enzymes carbohydrate metabolism dimethylsulphoxide iodoacetate solid Ehrlich carcinoma Treatment of tumor-bearing mice with LD12.5 values of iodoacetate; IAA (1.84 mg/100g b.w.) and/or dimethylsulphoxide; DMSO (350 mg/ 100g b.w.) significantly increased the cumulative mean survival time and percentage of survivors and reduced the mean tumor weight, compared to tumor-bearing controls, however, a more pronounced effect is recorded in the combined treatment. Also, an increase in the life span (ILS%) and tumor growth inhibition ratio (T/C%) are reported and amounted to 145.78 and 43.80%, 195.54 and 61.30% and 220.77 and 78.40% in IAA, DMSO and combined-treated groups, respectively. Results obtained from biochemical studies reveal that a single IAA treatment of tumor-bearing mice significantly increased the levels of plasma lactate dehydrogenase (LDH) activity, while it also significantly decreased the levels of plasma glucose and liver total protein, RNA and DNA, compared to normal controls. On the other hand, a single DMSO treatment significantly elevated the activities of blood antioxidant enzymes, i.e. glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PDH) and decreased the liver RNA and DNA levels. Combined treatment increased significantly the levels of plasma LDH and erythrocytes G6PDH activities, as well as liver glycogen, and in contrast it decreased the levels of liver total protein, RNA and DNA, compared to normal controls.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.36 n.2 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200015en10.4067/S0716-97602003000200015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antioxidant enzymes carbohydrate metabolism dimethylsulphoxide iodoacetate solid Ehrlich carcinoma
spellingShingle	antioxidant enzymes carbohydrate metabolism dimethylsulphoxide iodoacetate solid Ehrlich carcinoma FAHIM,FAWZIA A ESMAT,AMR Y MADY,ESSAM A IBRAHIM,EMAD K Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice
description	Treatment of tumor-bearing mice with LD12.5 values of iodoacetate; IAA (1.84 mg/100g b.w.) and/or dimethylsulphoxide; DMSO (350 mg/ 100g b.w.) significantly increased the cumulative mean survival time and percentage of survivors and reduced the mean tumor weight, compared to tumor-bearing controls, however, a more pronounced effect is recorded in the combined treatment. Also, an increase in the life span (ILS%) and tumor growth inhibition ratio (T/C%) are reported and amounted to 145.78 and 43.80%, 195.54 and 61.30% and 220.77 and 78.40% in IAA, DMSO and combined-treated groups, respectively. Results obtained from biochemical studies reveal that a single IAA treatment of tumor-bearing mice significantly increased the levels of plasma lactate dehydrogenase (LDH) activity, while it also significantly decreased the levels of plasma glucose and liver total protein, RNA and DNA, compared to normal controls. On the other hand, a single DMSO treatment significantly elevated the activities of blood antioxidant enzymes, i.e. glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PDH) and decreased the liver RNA and DNA levels. Combined treatment increased significantly the levels of plasma LDH and erythrocytes G6PDH activities, as well as liver glycogen, and in contrast it decreased the levels of liver total protein, RNA and DNA, compared to normal controls.
author	FAHIM,FAWZIA A ESMAT,AMR Y MADY,ESSAM A IBRAHIM,EMAD K
author_facet	FAHIM,FAWZIA A ESMAT,AMR Y MADY,ESSAM A IBRAHIM,EMAD K
author_sort	FAHIM,FAWZIA A
title	Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice
title_short	Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice
title_full	Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice
title_fullStr	Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice
title_full_unstemmed	Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice
title_sort	antitumor activities of iodoacetate and dimethylsulphoxide against solid ehrlich carcinoma growth in mice
publisher	Sociedad de Biología de Chile
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200015
work_keys_str_mv	AT fahimfawziaa antitumoractivitiesofiodoacetateanddimethylsulphoxideagainstsolidehrlichcarcinomagrowthinmice AT esmatamry antitumoractivitiesofiodoacetateanddimethylsulphoxideagainstsolidehrlichcarcinomagrowthinmice AT madyessama antitumoractivitiesofiodoacetateanddimethylsulphoxideagainstsolidehrlichcarcinomagrowthinmice AT ibrahimemadk antitumoractivitiesofiodoacetateanddimethylsulphoxideagainstsolidehrlichcarcinomagrowthinmice
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Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice

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