p53 Codon 72 Polymorphism and Risk of Cervical Cancer

p53 Codon 72 Polymorphism and Risk of Cervical Cancer

Storey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compa...

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Autores principales: OJEDA,JOSÉ M, AMPUERO,SANDRA, ROJAS,PATRICIO, PRADO,RODRIGO, ALLENDE,JORGE E, BARTON,SARA A, CHAKRABORTY,RANAJIT, ROTHHAMMER,FRANCISCO
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2003
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200017
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spelling oai:scielo:S0716-976020030002000172003-11-19p53 Codon 72 Polymorphism and Risk of Cervical CancerOJEDA,JOSÉ MAMPUERO,SANDRAROJAS,PATRICIOPRADO,RODRIGOALLENDE,JORGE EBARTON,SARA ACHAKRABORTY,RANAJITROTHHAMMER,FRANCISCOStorey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. These authors further noted that in the United Kingdom, individuals homozygous for the arginine allele were several times more susceptible to HPV-associated tumorigenesis that proline/arginine heterozygotes. Subsequent studies in different countries failed to unanimously confirm this association. Motivated by the high incidence of CC in Chile, we undertook a case control study obtaining the following frequencies for genotypes PP, AP and AA in 60 ICC cases and 53 carefully selected controls: 0.067, 0.250, 0.683 and 0.075, 0.453, 0.472 respectively. A significant difference (X² = 3.19 p < 0.02) and an odds ratio of 2.62 supported Storey et al (1998)'s results. In addition, rejecting previous hypotheses about the world distribution of the p53 codon 72 polymorphism, we conclude that this distribution most likely represents ancient human dispersal routes. Several methodological and biological explanations for the results obtained in previous negative association studies are briefly discussed.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.36 n.2 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200017en10.4067/S0716-97602003000200017
institution Scielo Chile
collection Scielo Chile
language English
description Storey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. These authors further noted that in the United Kingdom, individuals homozygous for the arginine allele were several times more susceptible to HPV-associated tumorigenesis that proline/arginine heterozygotes. Subsequent studies in different countries failed to unanimously confirm this association. Motivated by the high incidence of CC in Chile, we undertook a case control study obtaining the following frequencies for genotypes PP, AP and AA in 60 ICC cases and 53 carefully selected controls: 0.067, 0.250, 0.683 and 0.075, 0.453, 0.472 respectively. A significant difference (X² = 3.19 p < 0.02) and an odds ratio of 2.62 supported Storey et al (1998)'s results. In addition, rejecting previous hypotheses about the world distribution of the p53 codon 72 polymorphism, we conclude that this distribution most likely represents ancient human dispersal routes. Several methodological and biological explanations for the results obtained in previous negative association studies are briefly discussed.
author OJEDA,JOSÉ M
AMPUERO,SANDRA
ROJAS,PATRICIO
PRADO,RODRIGO
ALLENDE,JORGE E
BARTON,SARA A
CHAKRABORTY,RANAJIT
ROTHHAMMER,FRANCISCO
spellingShingle OJEDA,JOSÉ M
AMPUERO,SANDRA
ROJAS,PATRICIO
PRADO,RODRIGO
ALLENDE,JORGE E
BARTON,SARA A
CHAKRABORTY,RANAJIT
ROTHHAMMER,FRANCISCO
p53 Codon 72 Polymorphism and Risk of Cervical Cancer
author_facet OJEDA,JOSÉ M
AMPUERO,SANDRA
ROJAS,PATRICIO
PRADO,RODRIGO
ALLENDE,JORGE E
BARTON,SARA A
CHAKRABORTY,RANAJIT
ROTHHAMMER,FRANCISCO
author_sort OJEDA,JOSÉ M
title p53 Codon 72 Polymorphism and Risk of Cervical Cancer
title_short p53 Codon 72 Polymorphism and Risk of Cervical Cancer
title_full p53 Codon 72 Polymorphism and Risk of Cervical Cancer
title_fullStr p53 Codon 72 Polymorphism and Risk of Cervical Cancer
title_full_unstemmed p53 Codon 72 Polymorphism and Risk of Cervical Cancer
title_sort p53 codon 72 polymorphism and risk of cervical cancer
publisher Sociedad de Biología de Chile
publishDate 2003
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200017
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