Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles

The well-established trophic role of CNTF upon neurons led to performing clinical trials in patients of neurodegenerative diseases. However, trials were suspended due to side effects such as severe weight loss, hyperalgesia, coughing, muscle cramps and pain. So far it is not known how CNTF triggers...

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Autores principales:	RAMIREZ,BEATRIZ U, RETAMAL,LEIRA, VERGARA,CECILIA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2003
Materias:	CNTF contraction and relaxation time denervation EMG fibrillation skeletal muscle
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300003
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spelling	oai:scielo:S0716-976020030003000032004-08-17Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal musclesRAMIREZ,BEATRIZ URETAMAL,LEIRAVERGARA,CECILIA CNTF contraction and relaxation time denervation EMG fibrillation skeletal muscle The well-established trophic role of CNTF upon neurons led to performing clinical trials in patients of neurodegenerative diseases. However, trials were suspended due to side effects such as severe weight loss, hyperalgesia, coughing, muscle cramps and pain. So far it is not known how CNTF triggers the problems related to skeletal muscle cramps and pain. CNTF has also been described as a myotrophic factor for denervated skeletal muscles, but the possibility that it affects innervated muscles has also been considered. Since a myotrophic factor could be a valuable tool for treatment of several muscle diseases, we studied the effects of low doses of CNTF delivered systemically by an osmotic pump, over the electrical and mechanical properties of innervated and denervated fast and slow muscles. CNTF induced spontaneous electrical discharges and slowed twitches in innervated muscles, but did not prevent the changes induced by denervation. We postulate that the spontaneous discharges induced by CNTF in innervated muscles may be the cause of the cramps, coughing, and muscle ache reported by patients. At low doses, CNTF does not exert its myotrophic role over denervated muscles but clearly affects the excitable and contractile properties of innervated muscles.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.36 n.3-4 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300003en10.4067/S0716-97602003000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	CNTF contraction and relaxation time denervation EMG fibrillation skeletal muscle
spellingShingle	CNTF contraction and relaxation time denervation EMG fibrillation skeletal muscle RAMIREZ,BEATRIZ U RETAMAL,LEIRA VERGARA,CECILIA Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
description	The well-established trophic role of CNTF upon neurons led to performing clinical trials in patients of neurodegenerative diseases. However, trials were suspended due to side effects such as severe weight loss, hyperalgesia, coughing, muscle cramps and pain. So far it is not known how CNTF triggers the problems related to skeletal muscle cramps and pain. CNTF has also been described as a myotrophic factor for denervated skeletal muscles, but the possibility that it affects innervated muscles has also been considered. Since a myotrophic factor could be a valuable tool for treatment of several muscle diseases, we studied the effects of low doses of CNTF delivered systemically by an osmotic pump, over the electrical and mechanical properties of innervated and denervated fast and slow muscles. CNTF induced spontaneous electrical discharges and slowed twitches in innervated muscles, but did not prevent the changes induced by denervation. We postulate that the spontaneous discharges induced by CNTF in innervated muscles may be the cause of the cramps, coughing, and muscle ache reported by patients. At low doses, CNTF does not exert its myotrophic role over denervated muscles but clearly affects the excitable and contractile properties of innervated muscles.
author	RAMIREZ,BEATRIZ U RETAMAL,LEIRA VERGARA,CECILIA
author_facet	RAMIREZ,BEATRIZ U RETAMAL,LEIRA VERGARA,CECILIA
author_sort	RAMIREZ,BEATRIZ U
title	Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
title_short	Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
title_full	Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
title_fullStr	Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
title_full_unstemmed	Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
title_sort	ciliary neurotrophic factor (cntf) affects the excitable and contractile properties of innervated skeletal muscles
publisher	Sociedad de Biología de Chile
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300003
work_keys_str_mv	AT ramirezbeatrizu ciliaryneurotrophicfactorcntfaffectstheexcitableandcontractilepropertiesofinnervatedskeletalmuscles AT retamalleira ciliaryneurotrophicfactorcntfaffectstheexcitableandcontractilepropertiesofinnervatedskeletalmuscles AT vergaracecilia ciliaryneurotrophicfactorcntfaffectstheexcitableandcontractilepropertiesofinnervatedskeletalmuscles
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Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles

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