The action of ovarian hormones in cardiovascular disease

The incidence of cardiovascular disease (CAD) differs between men and women, in part because of differences in risk factors and hormones. This sexual dimorphism means a lower incidence in atherosclerotic diseases in premenopausal women, which subsequently rises in postmenopausal women to eventually...

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Autores principales:	MEDINA,RODOLFO A, ARANDA,EVELYN, VERDUGO,CESAR, KATO,SUMIE, OWEN,GARETH I
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2003
Materias:	hormone replacement therapy (HRT) oral contraceptives atherosclerosis cardiovascular disease estrogen progestins venous thrombosis myocardial infarction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300005
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spelling	oai:scielo:S0716-976020030003000052004-08-17The action of ovarian hormones in cardiovascular diseaseMEDINA,RODOLFO AARANDA,EVELYNVERDUGO,CESARKATO,SUMIEOWEN,GARETH I hormone replacement therapy (HRT) oral contraceptives atherosclerosis cardiovascular disease estrogen progestins venous thrombosis myocardial infarction The incidence of cardiovascular disease (CAD) differs between men and women, in part because of differences in risk factors and hormones. This sexual dimorphism means a lower incidence in atherosclerotic diseases in premenopausal women, which subsequently rises in postmenopausal women to eventually equal that of men. These observations point towards estrogen and progesterone playing a lifetime protective role against CAD in women. As exogenous estrogen and estrogen plus progesterone preparations produce significant reductions in low-density lipoprotein (LDL) cholesterol levels and significant increases in high-density lipoprotein (HDL) cholesterol, this should in theory lower the risk of CAD. However, results from oral contraceptive (OC) use and combined estrogen and progesterone hormone replacement therapy (HRT) have suggested that hormone replacement regimes do not provide cardiovascular protection. In fact, depending on the preparation and the presence or absence of genetic risk factors, an increased risk of cardiovascular diseases such as venous thrombosis, myocardial infarction (MI) and stroke have been observed. Interestingly, in the majority of studies the increase in risk was highest in the first year, after which an increase in risk was not observed, and in some studies a lower risk of CAD was evident after four or five years of exogenous hormone administration. While the debate continues about the merits of HRT, and several good reviews exist on the statistics of CAD in relation to exogenous hormones, we have decided to review the literature to piece together the physiological actions of estrogen and progesterone preparations on the individual mechanistic components leading to CAD; namely, the altered endothelium and the haemostatic balance between coagulation and fibrinolysis. We present possible mechanisms for how HRT and OCs protect against MI in the absence of cardiovascular risk factors but increase the incidence of MI in their presence. We also speculate on the roles played by hormones on the short- and long-term risks of cardiovascular disease.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.36 n.3-4 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300005en10.4067/S0716-97602003000300005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	hormone replacement therapy (HRT) oral contraceptives atherosclerosis cardiovascular disease estrogen progestins venous thrombosis myocardial infarction
spellingShingle	hormone replacement therapy (HRT) oral contraceptives atherosclerosis cardiovascular disease estrogen progestins venous thrombosis myocardial infarction MEDINA,RODOLFO A ARANDA,EVELYN VERDUGO,CESAR KATO,SUMIE OWEN,GARETH I The action of ovarian hormones in cardiovascular disease
description	The incidence of cardiovascular disease (CAD) differs between men and women, in part because of differences in risk factors and hormones. This sexual dimorphism means a lower incidence in atherosclerotic diseases in premenopausal women, which subsequently rises in postmenopausal women to eventually equal that of men. These observations point towards estrogen and progesterone playing a lifetime protective role against CAD in women. As exogenous estrogen and estrogen plus progesterone preparations produce significant reductions in low-density lipoprotein (LDL) cholesterol levels and significant increases in high-density lipoprotein (HDL) cholesterol, this should in theory lower the risk of CAD. However, results from oral contraceptive (OC) use and combined estrogen and progesterone hormone replacement therapy (HRT) have suggested that hormone replacement regimes do not provide cardiovascular protection. In fact, depending on the preparation and the presence or absence of genetic risk factors, an increased risk of cardiovascular diseases such as venous thrombosis, myocardial infarction (MI) and stroke have been observed. Interestingly, in the majority of studies the increase in risk was highest in the first year, after which an increase in risk was not observed, and in some studies a lower risk of CAD was evident after four or five years of exogenous hormone administration. While the debate continues about the merits of HRT, and several good reviews exist on the statistics of CAD in relation to exogenous hormones, we have decided to review the literature to piece together the physiological actions of estrogen and progesterone preparations on the individual mechanistic components leading to CAD; namely, the altered endothelium and the haemostatic balance between coagulation and fibrinolysis. We present possible mechanisms for how HRT and OCs protect against MI in the absence of cardiovascular risk factors but increase the incidence of MI in their presence. We also speculate on the roles played by hormones on the short- and long-term risks of cardiovascular disease.
author	MEDINA,RODOLFO A ARANDA,EVELYN VERDUGO,CESAR KATO,SUMIE OWEN,GARETH I
author_facet	MEDINA,RODOLFO A ARANDA,EVELYN VERDUGO,CESAR KATO,SUMIE OWEN,GARETH I
author_sort	MEDINA,RODOLFO A
title	The action of ovarian hormones in cardiovascular disease
title_short	The action of ovarian hormones in cardiovascular disease
title_full	The action of ovarian hormones in cardiovascular disease
title_fullStr	The action of ovarian hormones in cardiovascular disease
title_full_unstemmed	The action of ovarian hormones in cardiovascular disease
title_sort	action of ovarian hormones in cardiovascular disease
publisher	Sociedad de Biología de Chile
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300005
work_keys_str_mv	AT medinarodolfoa theactionofovarianhormonesincardiovasculardisease AT arandaevelyn theactionofovarianhormonesincardiovasculardisease AT verdugocesar theactionofovarianhormonesincardiovasculardisease AT katosumie theactionofovarianhormonesincardiovasculardisease AT owengarethi theactionofovarianhormonesincardiovasculardisease AT medinarodolfoa actionofovarianhormonesincardiovasculardisease AT arandaevelyn actionofovarianhormonesincardiovasculardisease AT verdugocesar actionofovarianhormonesincardiovasculardisease AT katosumie actionofovarianhormonesincardiovasculardisease AT owengarethi actionofovarianhormonesincardiovasculardisease
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The action of ovarian hormones in cardiovascular disease

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