Diet and Endothelial Function

Endothelial dysfunction is one of the earliest events in atherogenesis. A consequence of endothelial damage is a lower availability of nitric oxide (NO), the most potent endogenous vasodilator. NO inhibits platelet aggregation, smooth muscle cell proliferation and adhesion of monocytes to endothelia...

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Autores principales:	CUEVAS,ADA M, GERMAIN,ALFREDO M
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Diet endothelial function nitric oxide vascular reactivity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200008
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spelling	oai:scielo:S0716-976020040002000082005-01-06Diet and Endothelial FunctionCUEVAS,ADA MGERMAIN,ALFREDO M Diet endothelial function nitric oxide vascular reactivity Endothelial dysfunction is one of the earliest events in atherogenesis. A consequence of endothelial damage is a lower availability of nitric oxide (NO), the most potent endogenous vasodilator. NO inhibits platelet aggregation, smooth muscle cell proliferation and adhesion of monocytes to endothelial cells. Endothelial dysfunction is present in patients with cardiovascular disease and/or coronary risk factors, such as hypertension, dyslipidemia, diabetes, smoking or hyperhomocysteinemia. At present, soluble markers and high resolution ultrasound of the brachial artery, have provided simple tools for the study of endothelial function and the effects of several interventions. It has been demonstrated that dietary factors may induce significant changes on vascular reactivity. Nutrients, such as fish oil, antioxidants, L-arginine, folic acid and soy protein have shown an improvement in endothelial function that can mediate, at least partially, the cardioprotective effects of these substances. Attention has been focused on dietary patterns in populations with lower prevalence of cardiovascular disease. There is some evidence suggesting that Mediterranean diet characterized by high consumption of vegetables, fish, olive oil and moderate wine consumption may have a positive effect on endothelial function. These results give us evidence on the significant role of diet on endothelial function and its impact on the pathogenesis of atherosclerosisinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.2 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200008en10.4067/S0716-97602004000200008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diet endothelial function nitric oxide vascular reactivity
spellingShingle	Diet endothelial function nitric oxide vascular reactivity CUEVAS,ADA M GERMAIN,ALFREDO M Diet and Endothelial Function
description	Endothelial dysfunction is one of the earliest events in atherogenesis. A consequence of endothelial damage is a lower availability of nitric oxide (NO), the most potent endogenous vasodilator. NO inhibits platelet aggregation, smooth muscle cell proliferation and adhesion of monocytes to endothelial cells. Endothelial dysfunction is present in patients with cardiovascular disease and/or coronary risk factors, such as hypertension, dyslipidemia, diabetes, smoking or hyperhomocysteinemia. At present, soluble markers and high resolution ultrasound of the brachial artery, have provided simple tools for the study of endothelial function and the effects of several interventions. It has been demonstrated that dietary factors may induce significant changes on vascular reactivity. Nutrients, such as fish oil, antioxidants, L-arginine, folic acid and soy protein have shown an improvement in endothelial function that can mediate, at least partially, the cardioprotective effects of these substances. Attention has been focused on dietary patterns in populations with lower prevalence of cardiovascular disease. There is some evidence suggesting that Mediterranean diet characterized by high consumption of vegetables, fish, olive oil and moderate wine consumption may have a positive effect on endothelial function. These results give us evidence on the significant role of diet on endothelial function and its impact on the pathogenesis of atherosclerosis
author	CUEVAS,ADA M GERMAIN,ALFREDO M
author_facet	CUEVAS,ADA M GERMAIN,ALFREDO M
author_sort	CUEVAS,ADA M
title	Diet and Endothelial Function
title_short	Diet and Endothelial Function
title_full	Diet and Endothelial Function
title_fullStr	Diet and Endothelial Function
title_full_unstemmed	Diet and Endothelial Function
title_sort	diet and endothelial function
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200008
work_keys_str_mv	AT cuevasadam dietandendothelialfunction AT germainalfredom dietandendothelialfunction
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Diet and Endothelial Function

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