Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells

We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 µg/ml) protected Jurkat T cells from AMVN-mediated oxidation and i...

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Autores principales:	VERSTRAETEN,SANDRA V., OTEIZA,PATRICIA I., FRAGA,CÉSAR G.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Epicatechin free radicals lipid oxidation membrane fluidity membrane permeability procyanidins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200016
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spelling	oai:scielo:S0716-976020040002000162005-01-06Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T CellsVERSTRAETEN,SANDRA V.OTEIZA,PATRICIA I.FRAGA,CÉSAR G. Epicatechin free radicals lipid oxidation membrane fluidity membrane permeability procyanidins We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 µg/ml) protected Jurkat T cells from AMVN-mediated oxidation and increased plasma membrane fluidity. These effects occurred in a concentration- and chain length-dependent manner. In liposomes, procyanidins prevented the Fe2+-induced permeabilization of the membrane. Together, these results support the hypothesis that procyanidins could interact with the polar headgroup of lipids, increasing membrane fluidity and also, preventing the access of molecules that could affect membrane integrityinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.2 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200016en10.4067/S0716-97602004000200016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Epicatechin free radicals lipid oxidation membrane fluidity membrane permeability procyanidins
spellingShingle	Epicatechin free radicals lipid oxidation membrane fluidity membrane permeability procyanidins VERSTRAETEN,SANDRA V. OTEIZA,PATRICIA I. FRAGA,CÉSAR G. Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells
description	We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 µg/ml) protected Jurkat T cells from AMVN-mediated oxidation and increased plasma membrane fluidity. These effects occurred in a concentration- and chain length-dependent manner. In liposomes, procyanidins prevented the Fe2+-induced permeabilization of the membrane. Together, these results support the hypothesis that procyanidins could interact with the polar headgroup of lipids, increasing membrane fluidity and also, preventing the access of molecules that could affect membrane integrity
author	VERSTRAETEN,SANDRA V. OTEIZA,PATRICIA I. FRAGA,CÉSAR G.
author_facet	VERSTRAETEN,SANDRA V. OTEIZA,PATRICIA I. FRAGA,CÉSAR G.
author_sort	VERSTRAETEN,SANDRA V.
title	Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells
title_short	Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells
title_full	Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells
title_fullStr	Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells
title_full_unstemmed	Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells
title_sort	membrane effects of cocoa procyanidins in liposomes and jurkat t cells
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200016
work_keys_str_mv	AT verstraetensandrav membraneeffectsofcocoaprocyanidinsinliposomesandjurkattcells AT oteizapatriciai membraneeffectsofcocoaprocyanidinsinliposomesandjurkattcells AT fragacesarg membraneeffectsofcocoaprocyanidinsinliposomesandjurkattcells
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Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells

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