Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep

Leptin, the product of the ob gene, has been proposed as a metabolic signal that regulates the secretion of GnRH/LH. This may be critical during prepubertal development to synchronize information about energy stores and the secretion of GnRH/LH. This study aimed to assess the effect of food restrict...

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Autores principales:	RECABARREN,SERGIO E, LOBOS,ALEJANDRO, TORRES,VERÓNICA, OYARZO,ROBERTO, SIR-PETERMANN,TERESA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	female sheep food restriction leptin LH puberty
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300003
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spelling	oai:scielo:S0716-976020040003000032005-03-14Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female SheepRECABARREN,SERGIO ELOBOS,ALEJANDROTORRES,VERÓNICAOYARZO,ROBERTOSIR-PETERMANN,TERESA female sheep food restriction leptin LH puberty Leptin, the product of the ob gene, has been proposed as a metabolic signal that regulates the secretion of GnRH/LH. This may be critical during prepubertal development to synchronize information about energy stores and the secretion of GnRH/LH. This study aimed to assess the effect of food restriction on the episodic secretion of leptin and LH in young female sheep. Five 20-week-old prepubertal females were fed a low-level diet for 10 weeks to maintain the body weight. Control females of the same age received food ad libitum. Blood samples were collected at 10-min intervals for six hours at 20, 26, and 30 weeks of age, and plasma leptin, LH, insulin and cortisol concentrations were measured. In the control group, no changes were found in pulsatile LH secretion characteristics. Mean LH concentrations and LH amplitude were lower in the food-restricted group than in the control group at 26 and 30 weeks of age. In the control group, pulsatile leptin secretion did not change. When compared to control lambs of the same age, the food-restricted group showed lower mean plasma leptin concentrations, pulse amplitude and plasma insulin levels, after 6 weeks of restriction (week 26), although by week 30, plasma leptin concentrations and plasma insulin rose to those of the control group. Leptin pulse frequency did not change, nor did mean plasma levels of insulin in the control group at any age studied. Mean plasma concentration of cortisol did not change within or between groups. These data suggest that plasma leptin concentrations may not be associated with the onset of puberty under regular feeding and natural photoperiod in lambs. Prolonged food restriction, however, induces metabolic adaptations that allow an increase of leptin during the final period, probably related to the development of some degree of insulin resistanceinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.3 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300003en10.4067/S0716-97602004000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	female sheep food restriction leptin LH puberty
spellingShingle	female sheep food restriction leptin LH puberty RECABARREN,SERGIO E LOBOS,ALEJANDRO TORRES,VERÓNICA OYARZO,ROBERTO SIR-PETERMANN,TERESA Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep
description	Leptin, the product of the ob gene, has been proposed as a metabolic signal that regulates the secretion of GnRH/LH. This may be critical during prepubertal development to synchronize information about energy stores and the secretion of GnRH/LH. This study aimed to assess the effect of food restriction on the episodic secretion of leptin and LH in young female sheep. Five 20-week-old prepubertal females were fed a low-level diet for 10 weeks to maintain the body weight. Control females of the same age received food ad libitum. Blood samples were collected at 10-min intervals for six hours at 20, 26, and 30 weeks of age, and plasma leptin, LH, insulin and cortisol concentrations were measured. In the control group, no changes were found in pulsatile LH secretion characteristics. Mean LH concentrations and LH amplitude were lower in the food-restricted group than in the control group at 26 and 30 weeks of age. In the control group, pulsatile leptin secretion did not change. When compared to control lambs of the same age, the food-restricted group showed lower mean plasma leptin concentrations, pulse amplitude and plasma insulin levels, after 6 weeks of restriction (week 26), although by week 30, plasma leptin concentrations and plasma insulin rose to those of the control group. Leptin pulse frequency did not change, nor did mean plasma levels of insulin in the control group at any age studied. Mean plasma concentration of cortisol did not change within or between groups. These data suggest that plasma leptin concentrations may not be associated with the onset of puberty under regular feeding and natural photoperiod in lambs. Prolonged food restriction, however, induces metabolic adaptations that allow an increase of leptin during the final period, probably related to the development of some degree of insulin resistance
author	RECABARREN,SERGIO E LOBOS,ALEJANDRO TORRES,VERÓNICA OYARZO,ROBERTO SIR-PETERMANN,TERESA
author_facet	RECABARREN,SERGIO E LOBOS,ALEJANDRO TORRES,VERÓNICA OYARZO,ROBERTO SIR-PETERMANN,TERESA
author_sort	RECABARREN,SERGIO E
title	Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep
title_short	Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep
title_full	Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep
title_fullStr	Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep
title_full_unstemmed	Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep
title_sort	secretory patterns of leptin and luteinizing hormone in food-restricted young female sheep
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300003
work_keys_str_mv	AT recabarrensergioe secretorypatternsofleptinandluteinizinghormoneinfoodrestrictedyoungfemalesheep AT lobosalejandro secretorypatternsofleptinandluteinizinghormoneinfoodrestrictedyoungfemalesheep AT torresveronica secretorypatternsofleptinandluteinizinghormoneinfoodrestrictedyoungfemalesheep AT oyarzoroberto secretorypatternsofleptinandluteinizinghormoneinfoodrestrictedyoungfemalesheep AT sirpetermannteresa secretorypatternsofleptinandluteinizinghormoneinfoodrestrictedyoungfemalesheep
_version_	1718441370003177472

Secretory Patterns of Leptin and Luteinizing Hormone in Food-Restricted Young Female Sheep

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