Molecular analysis of the eighteen most frequent mutations in the BRCA1 gene in 63 Chilean breast cancer families

Molecular analysis of the eighteen most frequent mutations in the BRCA1 gene in 63 Chilean breast cancer families

BRCA1 gene mutations account for nearly all families with multiple cases of both early onset breast and/or ovarian cancer and about 30% of hereditary breast cancer. Although to date more than 1,237 distinct mutations, polymorphisms, and variants have been described, several mutations have been found...

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Autores principales: JARA,LILIAN, AMPUERO,SANDRA, SANTIBÁÑEZ,EUDOCIA, SECCIA,LORENA, RODRÍGUEZ,JUAN, BUSTAMANTE,MARIO, LAY-SON,GUILLERMO, OJEDA,JOSÉ MANUEL, REYES,JOSÉ MIGUEL, BLANCO,RAFAEL
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2004
Materias:
BRCA1 gene
frequent mutations
polymorphism
4185delCAAG
new mutation
Chilean population
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300011
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