Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles

Dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs) interact during EC coupling within calcium release units, CRUs. The location of the two channels and their positioning are related to their role in EC coupling. als DHPR and RyR1 of skeletal muscle form interlocked arrays. Groups of fo...

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Autor principal:	FRANZINI-ARMSTRONG,CLARA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Calcium release units dihydropyridine receptors ryanodine receptors transverse tubules sarcoplasmic reticulum
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400003
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spelling	oai:scielo:S0716-976020040004000032005-06-02Functional implications of RyR-DHPR relationships in skeletal and cardiac musclesFRANZINI-ARMSTRONG,CLARA Calcium release units dihydropyridine receptors ryanodine receptors transverse tubules sarcoplasmic reticulum Dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs) interact during EC coupling within calcium release units, CRUs. The location of the two channels and their positioning are related to their role in EC coupling. als DHPR and RyR1 of skeletal muscle form interlocked arrays. Groups of four DHPRs (forming a tetrad) are located on alternate RyR1s. This association provides the structural framework for reciprocal signaling between the two channels. RyR3 are present in some skeletal muscles in association with RyR1 and in ratios up to 1:1. RyR3 neither induce formation of tetrads by DHPRs nor sustain EC coupling. RyR3 are located in a parajunctional position, in proximity of the RyR1-DHPR complexes, and they may be indirectly activated by calcium liberated via the RyR1 channels. RyR2 have two locations in cardiac muscle. One is at CRUs that contain DHPRs and RyRs. In these cardiac CRUs, RyR2 and a1c DHPR are in proximity of each other, but not closely linked, so that they may not have a direct molecular interaction. A second location of RyR2 is on SR cisternae that are not attached to surface membrane/T tubules. The RyR2 in these cisternae, which are often several microns away from any DHPRs, must necessarily be activated indirectly.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400003en10.4067/S0716-97602004000400003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Calcium release units dihydropyridine receptors ryanodine receptors transverse tubules sarcoplasmic reticulum
spellingShingle	Calcium release units dihydropyridine receptors ryanodine receptors transverse tubules sarcoplasmic reticulum FRANZINI-ARMSTRONG,CLARA Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles
description	Dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs) interact during EC coupling within calcium release units, CRUs. The location of the two channels and their positioning are related to their role in EC coupling. als DHPR and RyR1 of skeletal muscle form interlocked arrays. Groups of four DHPRs (forming a tetrad) are located on alternate RyR1s. This association provides the structural framework for reciprocal signaling between the two channels. RyR3 are present in some skeletal muscles in association with RyR1 and in ratios up to 1:1. RyR3 neither induce formation of tetrads by DHPRs nor sustain EC coupling. RyR3 are located in a parajunctional position, in proximity of the RyR1-DHPR complexes, and they may be indirectly activated by calcium liberated via the RyR1 channels. RyR2 have two locations in cardiac muscle. One is at CRUs that contain DHPRs and RyRs. In these cardiac CRUs, RyR2 and a1c DHPR are in proximity of each other, but not closely linked, so that they may not have a direct molecular interaction. A second location of RyR2 is on SR cisternae that are not attached to surface membrane/T tubules. The RyR2 in these cisternae, which are often several microns away from any DHPRs, must necessarily be activated indirectly.
author	FRANZINI-ARMSTRONG,CLARA
author_facet	FRANZINI-ARMSTRONG,CLARA
author_sort	FRANZINI-ARMSTRONG,CLARA
title	Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles
title_short	Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles
title_full	Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles
title_fullStr	Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles
title_full_unstemmed	Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles
title_sort	functional implications of ryr-dhpr relationships in skeletal and cardiac muscles
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400003
work_keys_str_mv	AT franziniarmstrongclara functionalimplicationsofryrdhprrelationshipsinskeletalandcardiacmuscles
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Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles

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