Redox regulation of RyR-mediated Ca2+ release in muscle and neurons

Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, wh...

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Autores principales:	HIDALGO,CECILIA, BULL,RICARDO, BEHRENS,M. ISABEL, DONOSO,PAULINA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Redox state ryanodine receptors sarcoplasmic/endoplasmic reticulum calcium release S-nitrosylation S-glutathionylation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400007
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spelling	oai:scielo:S0716-976020040004000072005-06-02Redox regulation of RyR-mediated Ca2+ release in muscle and neuronsHIDALGO,CECILIABULL,RICARDOBEHRENS,M. ISABELDONOSO,PAULINA Redox state ryanodine receptors sarcoplasmic/endoplasmic reticulum calcium release S-nitrosylation S-glutathionylation Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400007en10.4067/S0716-97602004000400007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Redox state ryanodine receptors sarcoplasmic/endoplasmic reticulum calcium release S-nitrosylation S-glutathionylation
spellingShingle	Redox state ryanodine receptors sarcoplasmic/endoplasmic reticulum calcium release S-nitrosylation S-glutathionylation HIDALGO,CECILIA BULL,RICARDO BEHRENS,M. ISABEL DONOSO,PAULINA Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
description	Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.
author	HIDALGO,CECILIA BULL,RICARDO BEHRENS,M. ISABEL DONOSO,PAULINA
author_facet	HIDALGO,CECILIA BULL,RICARDO BEHRENS,M. ISABEL DONOSO,PAULINA
author_sort	HIDALGO,CECILIA
title	Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
title_short	Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
title_full	Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
title_fullStr	Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
title_full_unstemmed	Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
title_sort	redox regulation of ryr-mediated ca2+ release in muscle and neurons
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400007
work_keys_str_mv	AT hidalgocecilia redoxregulationofryrmediatedca2releaseinmuscleandneurons AT bullricardo redoxregulationofryrmediatedca2releaseinmuscleandneurons AT behrensmisabel redoxregulationofryrmediatedca2releaseinmuscleandneurons AT donosopaulina redoxregulationofryrmediatedca2releaseinmuscleandneurons
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Redox regulation of RyR-mediated Ca2+ release in muscle and neurons

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