Inositol 1,4,5-trisphosphate receptors in the heart

Inositol 1,4,5-trisphosphate (InsP3) is an established calcium-mobilizing messenger, which is well-known to activate Ca2+ signaling in many cell types. Contractile cardiomyocytes express hormone receptors that are coupled to the production of InsP3. Such cardioactive hormones, including endothelin,...

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Autores principales:	MACKENZIE,LAUREN, RODERICK,H. LLEWELYN, PROVEN,ANDREW, CONWAY,STUART J, BOOTMAN,MARTIN D
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Calcium cardiac inositol arrhythmia ryanodine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400008
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spelling	oai:scielo:S0716-976020040004000082005-06-02Inositol 1,4,5-trisphosphate receptors in the heartMACKENZIE,LAURENRODERICK,H. LLEWELYNPROVEN,ANDREWCONWAY,STUART JBOOTMAN,MARTIN D Calcium cardiac inositol arrhythmia ryanodine Inositol 1,4,5-trisphosphate (InsP3) is an established calcium-mobilizing messenger, which is well-known to activate Ca2+ signaling in many cell types. Contractile cardiomyocytes express hormone receptors that are coupled to the production of InsP3. Such cardioactive hormones, including endothelin, may have profound inotropic and arrhythmogenic actions, but it is unclear whether InsP3 underlies any of these effects. We have examined the expression and localization of InsP3 receptors (InsP3Rs), and the potential role of InsP3 in modulating cardiac excitation-contraction coupling (EC coupling). Stimulation of electrically-paced atrial and ventricular myocytes with a membrane-permeant InsP3 ester was found to evoke an increase in the amplitudes of action potential-evoked Ca2+ transients and to cause pro-arrhythmic diastolic Ca2+ transients. All the effects of the InsP3 ester could be blocked using a membrane-permeant antagonist of InsP3Rs (2-aminoethoxydiphenyl borate; 2-APB). Furthermore, 2-APB blocked arrhythmias evoked by endothelin and delayed the onset of positive inotropic responses. Our data indicate that atrial and ventricular cardiomyocytes express functional InsP3Rs, and these channels have the potential to influence EC coupling.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400008en10.4067/S0716-97602004000400008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Calcium cardiac inositol arrhythmia ryanodine
spellingShingle	Calcium cardiac inositol arrhythmia ryanodine MACKENZIE,LAUREN RODERICK,H. LLEWELYN PROVEN,ANDREW CONWAY,STUART J BOOTMAN,MARTIN D Inositol 1,4,5-trisphosphate receptors in the heart
description	Inositol 1,4,5-trisphosphate (InsP3) is an established calcium-mobilizing messenger, which is well-known to activate Ca2+ signaling in many cell types. Contractile cardiomyocytes express hormone receptors that are coupled to the production of InsP3. Such cardioactive hormones, including endothelin, may have profound inotropic and arrhythmogenic actions, but it is unclear whether InsP3 underlies any of these effects. We have examined the expression and localization of InsP3 receptors (InsP3Rs), and the potential role of InsP3 in modulating cardiac excitation-contraction coupling (EC coupling). Stimulation of electrically-paced atrial and ventricular myocytes with a membrane-permeant InsP3 ester was found to evoke an increase in the amplitudes of action potential-evoked Ca2+ transients and to cause pro-arrhythmic diastolic Ca2+ transients. All the effects of the InsP3 ester could be blocked using a membrane-permeant antagonist of InsP3Rs (2-aminoethoxydiphenyl borate; 2-APB). Furthermore, 2-APB blocked arrhythmias evoked by endothelin and delayed the onset of positive inotropic responses. Our data indicate that atrial and ventricular cardiomyocytes express functional InsP3Rs, and these channels have the potential to influence EC coupling.
author	MACKENZIE,LAUREN RODERICK,H. LLEWELYN PROVEN,ANDREW CONWAY,STUART J BOOTMAN,MARTIN D
author_facet	MACKENZIE,LAUREN RODERICK,H. LLEWELYN PROVEN,ANDREW CONWAY,STUART J BOOTMAN,MARTIN D
author_sort	MACKENZIE,LAUREN
title	Inositol 1,4,5-trisphosphate receptors in the heart
title_short	Inositol 1,4,5-trisphosphate receptors in the heart
title_full	Inositol 1,4,5-trisphosphate receptors in the heart
title_fullStr	Inositol 1,4,5-trisphosphate receptors in the heart
title_full_unstemmed	Inositol 1,4,5-trisphosphate receptors in the heart
title_sort	inositol 1,4,5-trisphosphate receptors in the heart
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400008
work_keys_str_mv	AT mackenzielauren inositol145trisphosphatereceptorsintheheart AT roderickhllewelyn inositol145trisphosphatereceptorsintheheart AT provenandrew inositol145trisphosphatereceptorsintheheart AT conwaystuartj inositol145trisphosphatereceptorsintheheart AT bootmanmartind inositol145trisphosphatereceptorsintheheart
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Inositol 1,4,5-trisphosphate receptors in the heart

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