To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?

To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems. The role of the NAADP system in physiologicalprocesses is being extensively investigated at the present time. The NAADP receptor and its associate...

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Autor principal: NUNES CHINI,EDUARDO
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2004
Materias:
NAADP
Ca2+
channels
cADPR
intracellular
second messenger
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400009
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spelling oai:scielo:S0716-976020040004000092005-06-02To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?NUNES CHINI,EDUARDO NAADP Ca2+ channels cADPR intracellular second messenger Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems. The role of the NAADP system in physiologicalprocesses is being extensively investigated at the present time. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiologicalprocesses including fertilization, T cell activation, and pancreaticsecretion. However, whether NAADP is a new second messenger ora tool for the discovery of a new Ca2+ channel is still an unansweredquestion. Research developed over the last two years has provided some important clues to whether NAADP is or not a physiological cellular messenger. In this short review, I will discuss some of these new findings that are helping us to find an answer to the important question: Is NAADP a second messenger or not?info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400009en10.4067/S0716-97602004000400009
institution Scielo Chile
collection Scielo Chile
language English
topic NAADP
Ca2+
channels
cADPR
intracellular
second messenger
spellingShingle NAADP
Ca2+
channels
cADPR
intracellular
second messenger
NUNES CHINI,EDUARDO
To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?
description Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems. The role of the NAADP system in physiologicalprocesses is being extensively investigated at the present time. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiologicalprocesses including fertilization, T cell activation, and pancreaticsecretion. However, whether NAADP is a new second messenger ora tool for the discovery of a new Ca2+ channel is still an unansweredquestion. Research developed over the last two years has provided some important clues to whether NAADP is or not a physiological cellular messenger. In this short review, I will discuss some of these new findings that are helping us to find an answer to the important question: Is NAADP a second messenger or not?
author NUNES CHINI,EDUARDO
author_facet NUNES CHINI,EDUARDO
author_sort NUNES CHINI,EDUARDO
title To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?
title_short To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?
title_full To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?
title_fullStr To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?
title_full_unstemmed To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?
title_sort to be or not to be… nicotinic acid adenine dinucleotide phosphate (naadp): a new intracellular second messenger?
publisher Sociedad de Biología de Chile
publishDate 2004
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400009
work_keys_str_mv AT nuneschinieduardo tobeornottobe8230nicotinicacidadeninedinucleotidephosphatenaadpanewintracellularsecondmessenger
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