Calmodulin and Calcium-release Channels

Calmodulin (CaM) is a ubiquitous cytosolic protein that plays a critical role in regulating cellular functions by altering the activity of a large number of ion channels. There are many examples for CaM directly mediating the feedback effects of Ca2+ on Ca2+ channels. Recently the molecular mechanis...

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Autores principales:	KASRI,NAEL NADIF, PARYS,JAN B., CALLEWAERT,GEERT, MISSIAEN,LUDWIG, DE SMEDT,HUMBERT
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	calmodulin calcium channels inositol 1,4,5-trisphosphate receptor
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400011
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spelling	oai:scielo:S0716-976020040004000112005-06-02Calmodulin and Calcium-release ChannelsKASRI,NAEL NADIFPARYS,JAN B.CALLEWAERT,GEERTMISSIAEN,LUDWIGDE SMEDT,HUMBERT calmodulin calcium channels inositol 1,4,5-trisphosphate receptor Calmodulin (CaM) is a ubiquitous cytosolic protein that plays a critical role in regulating cellular functions by altering the activity of a large number of ion channels. There are many examples for CaM directly mediating the feedback effects of Ca2+ on Ca2+ channels. Recently the molecular mechanisms by which CaM interacts with voltage-gated Ca2+ channels, Ca2+-activated K+ channels and ryanodine receptors have been clarified. CaM plays an important role in regulating these ion channels through lobe-specific Ca2+ detection. CaM seems to behave as a channel subunit. It binds at low [Ca2+] and undergoes conformational changes upon binding of Ca2+, leading to an interaction with another part of the channel to regulate its gating. Here we focus on the mechanism by which CaM regulates the inositol 1,4,5-trisphosphate receptor (IP3R). Although the IP3R is inhibited by CaM and by other CaM-like proteins in the presence of Ca2+, we conclude that CaM does not act as the Ca2+ sensor for IP3R function. Furthermore we discuss a novel Ca2+-induced Ca2+-release mechanism found in A7r5 (embryonic rat aorta) and 16HBE14o- (human bronchial mucosa) cells for which CaM acts as a Ca2+ sensorinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400011en10.4067/S0716-97602004000400011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	calmodulin calcium channels inositol 1,4,5-trisphosphate receptor
spellingShingle	calmodulin calcium channels inositol 1,4,5-trisphosphate receptor KASRI,NAEL NADIF PARYS,JAN B. CALLEWAERT,GEERT MISSIAEN,LUDWIG DE SMEDT,HUMBERT Calmodulin and Calcium-release Channels
description	Calmodulin (CaM) is a ubiquitous cytosolic protein that plays a critical role in regulating cellular functions by altering the activity of a large number of ion channels. There are many examples for CaM directly mediating the feedback effects of Ca2+ on Ca2+ channels. Recently the molecular mechanisms by which CaM interacts with voltage-gated Ca2+ channels, Ca2+-activated K+ channels and ryanodine receptors have been clarified. CaM plays an important role in regulating these ion channels through lobe-specific Ca2+ detection. CaM seems to behave as a channel subunit. It binds at low [Ca2+] and undergoes conformational changes upon binding of Ca2+, leading to an interaction with another part of the channel to regulate its gating. Here we focus on the mechanism by which CaM regulates the inositol 1,4,5-trisphosphate receptor (IP3R). Although the IP3R is inhibited by CaM and by other CaM-like proteins in the presence of Ca2+, we conclude that CaM does not act as the Ca2+ sensor for IP3R function. Furthermore we discuss a novel Ca2+-induced Ca2+-release mechanism found in A7r5 (embryonic rat aorta) and 16HBE14o- (human bronchial mucosa) cells for which CaM acts as a Ca2+ sensor
author	KASRI,NAEL NADIF PARYS,JAN B. CALLEWAERT,GEERT MISSIAEN,LUDWIG DE SMEDT,HUMBERT
author_facet	KASRI,NAEL NADIF PARYS,JAN B. CALLEWAERT,GEERT MISSIAEN,LUDWIG DE SMEDT,HUMBERT
author_sort	KASRI,NAEL NADIF
title	Calmodulin and Calcium-release Channels
title_short	Calmodulin and Calcium-release Channels
title_full	Calmodulin and Calcium-release Channels
title_fullStr	Calmodulin and Calcium-release Channels
title_full_unstemmed	Calmodulin and Calcium-release Channels
title_sort	calmodulin and calcium-release channels
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400011
work_keys_str_mv	AT kasrinaelnadif calmodulinandcalciumreleasechannels AT parysjanb calmodulinandcalciumreleasechannels AT callewaertgeert calmodulinandcalciumreleasechannels AT missiaenludwig calmodulinandcalciumreleasechannels AT desmedthumbert calmodulinandcalciumreleasechannels
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Calmodulin and Calcium-release Channels

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