Ca2+ entry, efflux and release in smooth muscle

Control of smooth muscle is vital for health. The major route to contraction is a rise in intracellular [Ca2+], determined by the entry and efflux of Ca2+ and release and re-uptake into the sarcoplasmic reticulum (SR). We review these processes in myometrium, to better understand excitation-contract...

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Autores principales:	MATTHEW,A, SHMYGOL,A, WRAY,SUSAN
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	uterus SR signalling Ca-ATPase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400017
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spelling	oai:scielo:S0716-976020040004000172005-06-02Ca2+ entry, efflux and release in smooth muscleMATTHEW,ASHMYGOL,AWRAY,SUSAN uterus SR signalling Ca-ATPase Control of smooth muscle is vital for health. The major route to contraction is a rise in intracellular [Ca2+], determined by the entry and efflux of Ca2+ and release and re-uptake into the sarcoplasmic reticulum (SR). We review these processes in myometrium, to better understand excitation-contraction coupling and develop strategies for preventing problematic labours. The main mechanism of elevating [Ca2+] is voltage-gated L-type channels, due to pacemaker activity, which can be modulated by agonists. The rise of [Ca2+] produces Ca-calmodulin and activates MLCK. This phosphorylates myosin and force results. Without Ca2+ entry uterine contraction fails. The Na/Ca exchanger (NCX) and plasma membrane Ca-ATPase (PMCA) remove Ca2+, with contributions of 30% and 70% respectively. Studies with PMCA-4 knockout mice show that it contributes to reducing [Ca2+] and relaxation. The SR contributes to relaxation by vectorially releasing Ca2+ to the efflux pathways, and thereby increasing their rates. Agonists binding produces IP3 which can release Ca from the SR but inhibition of SR Ca2+ release increases contractions and Ca2+ transients. It is suggested that SR Ca2+ targets K+ channels on the surface membrane and thereby feedback to inhibit excitability and contraction.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400017en10.4067/S0716-97602004000400017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	uterus SR signalling Ca-ATPase
spellingShingle	uterus SR signalling Ca-ATPase MATTHEW,A SHMYGOL,A WRAY,SUSAN Ca2+ entry, efflux and release in smooth muscle
description	Control of smooth muscle is vital for health. The major route to contraction is a rise in intracellular [Ca2+], determined by the entry and efflux of Ca2+ and release and re-uptake into the sarcoplasmic reticulum (SR). We review these processes in myometrium, to better understand excitation-contraction coupling and develop strategies for preventing problematic labours. The main mechanism of elevating [Ca2+] is voltage-gated L-type channels, due to pacemaker activity, which can be modulated by agonists. The rise of [Ca2+] produces Ca-calmodulin and activates MLCK. This phosphorylates myosin and force results. Without Ca2+ entry uterine contraction fails. The Na/Ca exchanger (NCX) and plasma membrane Ca-ATPase (PMCA) remove Ca2+, with contributions of 30% and 70% respectively. Studies with PMCA-4 knockout mice show that it contributes to reducing [Ca2+] and relaxation. The SR contributes to relaxation by vectorially releasing Ca2+ to the efflux pathways, and thereby increasing their rates. Agonists binding produces IP3 which can release Ca from the SR but inhibition of SR Ca2+ release increases contractions and Ca2+ transients. It is suggested that SR Ca2+ targets K+ channels on the surface membrane and thereby feedback to inhibit excitability and contraction.
author	MATTHEW,A SHMYGOL,A WRAY,SUSAN
author_facet	MATTHEW,A SHMYGOL,A WRAY,SUSAN
author_sort	MATTHEW,A
title	Ca2+ entry, efflux and release in smooth muscle
title_short	Ca2+ entry, efflux and release in smooth muscle
title_full	Ca2+ entry, efflux and release in smooth muscle
title_fullStr	Ca2+ entry, efflux and release in smooth muscle
title_full_unstemmed	Ca2+ entry, efflux and release in smooth muscle
title_sort	ca2+ entry, efflux and release in smooth muscle
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400017
work_keys_str_mv	AT matthewa ca2entryeffluxandreleaseinsmoothmuscle AT shmygola ca2entryeffluxandreleaseinsmoothmuscle AT wraysusan ca2entryeffluxandreleaseinsmoothmuscle
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Ca2+ entry, efflux and release in smooth muscle

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