Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells

A capacitative Ca2+ entry (CCE) pathway, activated by depletion of intracellular Ca2+ stores, is thought to mediate much of the Ca2+ entry evoked by receptors that stimulate phospholipase C (PLC). However, in A7r5 vascular smooth muscle cells, vasopressin, which stimulates PLC, empties intracellular...

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Autores principales:	TAYLOR,COLIN W, MONEER,ZAHID
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Ca2+ entry smooth muscle archidonic acid nitric oxide cyclic GMP
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400020
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spelling	oai:scielo:S0716-976020040004000202005-06-02Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cellsTAYLOR,COLIN WMONEER,ZAHID Ca2+ entry smooth muscle archidonic acid nitric oxide cyclic GMP A capacitative Ca2+ entry (CCE) pathway, activated by depletion of intracellular Ca2+ stores, is thought to mediate much of the Ca2+ entry evoked by receptors that stimulate phospholipase C (PLC). However, in A7r5 vascular smooth muscle cells, vasopressin, which stimulates PLC, empties intracellular Ca2+ stores but simultaneously inhibits their ability to activate CCE. The diacylglycerol produced with the IP3 that empties the stores is metabolized to arachidonic and this leads to activation of nitric oxide (NO) synthase, production of NO and cyclic GMP, and consequent activation of protein kinase G. The latter inhibits CCE. In parallel, NO directly activates a non-capacitative Ca2+ entry (NCCE) pathway, which is entirely responsible for the Ca2+ entry that occurs in the presence of vasopressin. This reciprocal regulation of two Ca2+ entry pathways ensures that there is sequential activation of first NCCE in the presence of vasopressin, and then a transient activation of CCE when vasopressin is removed. We suggest that the two routes for Ca2+ entry may selectively direct Ca2+ to processes that mediate activation and then recovery of the cell.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400020en10.4067/S0716-97602004000400020
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ca2+ entry smooth muscle archidonic acid nitric oxide cyclic GMP
spellingShingle	Ca2+ entry smooth muscle archidonic acid nitric oxide cyclic GMP TAYLOR,COLIN W MONEER,ZAHID Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells
description	A capacitative Ca2+ entry (CCE) pathway, activated by depletion of intracellular Ca2+ stores, is thought to mediate much of the Ca2+ entry evoked by receptors that stimulate phospholipase C (PLC). However, in A7r5 vascular smooth muscle cells, vasopressin, which stimulates PLC, empties intracellular Ca2+ stores but simultaneously inhibits their ability to activate CCE. The diacylglycerol produced with the IP3 that empties the stores is metabolized to arachidonic and this leads to activation of nitric oxide (NO) synthase, production of NO and cyclic GMP, and consequent activation of protein kinase G. The latter inhibits CCE. In parallel, NO directly activates a non-capacitative Ca2+ entry (NCCE) pathway, which is entirely responsible for the Ca2+ entry that occurs in the presence of vasopressin. This reciprocal regulation of two Ca2+ entry pathways ensures that there is sequential activation of first NCCE in the presence of vasopressin, and then a transient activation of CCE when vasopressin is removed. We suggest that the two routes for Ca2+ entry may selectively direct Ca2+ to processes that mediate activation and then recovery of the cell.
author	TAYLOR,COLIN W MONEER,ZAHID
author_facet	TAYLOR,COLIN W MONEER,ZAHID
author_sort	TAYLOR,COLIN W
title	Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells
title_short	Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells
title_full	Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells
title_fullStr	Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells
title_full_unstemmed	Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells
title_sort	regulation of capacitative and non-capacitative ca2+ entry in a7r5 vascular smooth muscle cells
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400020
work_keys_str_mv	AT taylorcolinw regulationofcapacitativeandnoncapacitativeca2entryina7r5vascularsmoothmusclecells AT moneerzahid regulationofcapacitativeandnoncapacitativeca2entryina7r5vascularsmoothmusclecells
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Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells

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