Local and global Ca2+ signals: physiology and pathophysiology

The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global...

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Autor principal:	PETERSEN,OLE H.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023
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spelling	oai:scielo:S0716-976020040004000232005-06-02Local and global Ca2+ signals: physiology and pathophysiologyPETERSEN,OLE H. Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023en10.4067/S0716-97602004000400023
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals
spellingShingle	Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals PETERSEN,OLE H. Local and global Ca2+ signals: physiology and pathophysiology
description	The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.
author	PETERSEN,OLE H.
author_facet	PETERSEN,OLE H.
author_sort	PETERSEN,OLE H.
title	Local and global Ca2+ signals: physiology and pathophysiology
title_short	Local and global Ca2+ signals: physiology and pathophysiology
title_full	Local and global Ca2+ signals: physiology and pathophysiology
title_fullStr	Local and global Ca2+ signals: physiology and pathophysiology
title_full_unstemmed	Local and global Ca2+ signals: physiology and pathophysiology
title_sort	local and global ca2+ signals: physiology and pathophysiology
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023
work_keys_str_mv	AT petersenoleh localandglobalca2signalsphysiologyandpathophysiology
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Local and global Ca2+ signals: physiology and pathophysiology

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