Endoplasmic reticulum calcium signaling in nerve cells

The endoplasmic reticulum (ER) is an important organelle involved in various types of signaling in nerve cells. The ER serves as a dynamic Ca2+ pool being thus involved in rapid signaling events associated with cell stimulation by either electrical (action potential) or chemical (neurotransmitters)...

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Autor principal:	VERKHRATSKY,ALEXEI
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	calcium signaling endoplasmic reticulum ryanodine receptors InsP3 receptors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400027
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spelling	oai:scielo:S0716-976020040004000272005-06-02Endoplasmic reticulum calcium signaling in nerve cellsVERKHRATSKY,ALEXEI calcium signaling endoplasmic reticulum ryanodine receptors InsP3 receptors The endoplasmic reticulum (ER) is an important organelle involved in various types of signaling in nerve cells. The ER serves as a dynamic Ca2+ pool being thus involved in rapid signaling events associated with cell stimulation by either electrical (action potential) or chemical (neurotransmitters) signals. This function is supported by Ca2+ release channels (InsP3 and ryanodine receptors) and SERCA Ca2+ pumps residing in the endomembrane. In addition the ER provides a specific environment for the posttranslational protein processing and transport of various molecules towards their final destination. In parallel, the ER acts as a "calcium tunnel," which facilitates Ca2+ movements within the cell by avoiding cytoplasmic routes. Finally the ER appears as a source of numerous signals aimed at the nucleus and involved in long-lasting adaptive cellular responses. All these important functions are controlled by intra-ER free Ca2+ which integrates various signaling events and establishes a link between fast signaling, associated with ER Ca2+ release/uptake, and long-lasting adaptive responses relying primarily on the regulation of protein synthesis. Disruption of ER Ca2+ homeostasis triggers several forms of cellular stress response and is intimately involved in neurodegeneration and neuronal cell deathinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400027en10.4067/S0716-97602004000400027
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	calcium signaling endoplasmic reticulum ryanodine receptors InsP3 receptors
spellingShingle	calcium signaling endoplasmic reticulum ryanodine receptors InsP3 receptors VERKHRATSKY,ALEXEI Endoplasmic reticulum calcium signaling in nerve cells
description	The endoplasmic reticulum (ER) is an important organelle involved in various types of signaling in nerve cells. The ER serves as a dynamic Ca2+ pool being thus involved in rapid signaling events associated with cell stimulation by either electrical (action potential) or chemical (neurotransmitters) signals. This function is supported by Ca2+ release channels (InsP3 and ryanodine receptors) and SERCA Ca2+ pumps residing in the endomembrane. In addition the ER provides a specific environment for the posttranslational protein processing and transport of various molecules towards their final destination. In parallel, the ER acts as a "calcium tunnel," which facilitates Ca2+ movements within the cell by avoiding cytoplasmic routes. Finally the ER appears as a source of numerous signals aimed at the nucleus and involved in long-lasting adaptive cellular responses. All these important functions are controlled by intra-ER free Ca2+ which integrates various signaling events and establishes a link between fast signaling, associated with ER Ca2+ release/uptake, and long-lasting adaptive responses relying primarily on the regulation of protein synthesis. Disruption of ER Ca2+ homeostasis triggers several forms of cellular stress response and is intimately involved in neurodegeneration and neuronal cell death
author	VERKHRATSKY,ALEXEI
author_facet	VERKHRATSKY,ALEXEI
author_sort	VERKHRATSKY,ALEXEI
title	Endoplasmic reticulum calcium signaling in nerve cells
title_short	Endoplasmic reticulum calcium signaling in nerve cells
title_full	Endoplasmic reticulum calcium signaling in nerve cells
title_fullStr	Endoplasmic reticulum calcium signaling in nerve cells
title_full_unstemmed	Endoplasmic reticulum calcium signaling in nerve cells
title_sort	endoplasmic reticulum calcium signaling in nerve cells
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400027
work_keys_str_mv	AT verkhratskyalexei endoplasmicreticulumcalciumsignalinginnervecells
_version_	1718441379212820480

Endoplasmic reticulum calcium signaling in nerve cells

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