Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells

Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	CARRASCO,MARÍA ANGÉLICA, JAIMOVICH,ENRIQUE, KEMMERLING,ULRIKE, HIDALGO,CECILIA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2004
Materias:	Calcium signals intracellular stores transcription oxidation neurons skeletal muscle
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400028
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602004000400028
record_format	dspace
spelling	oai:scielo:S0716-976020040004000282005-06-02Signal transduction and gene expression regulated by calcium release from internal stores in excitable cellsCARRASCO,MARÍA ANGÉLICAJAIMOVICH,ENRIQUEKEMMERLING,ULRIKEHIDALGO,CECILIA Calcium signals intracellular stores transcription oxidation neurons skeletal muscle Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed only recently. In this tissue, most cytoplasmic and nuclear calcium signals originate from calcium release from internal stores, mediated either by ryanodine receptor (RyR) or IP3 receptor (IP3R) channels. The latter are located both in the sarcoplasmic reticulum (SR) and in the nuclear membrane, and their activation results in long-lasting nuclear calcium increase. The calcium signals mediated by RyR and IP3R are very different in kinetics, amplitude and subcellular localization; an open question is whether these differences are differentially sensed by transcription factors. In neurons, it is well established that calcium entry through L-type calcium channels and NMDA receptors plays a role in the regulation of gene expression. Increasing evidence, however, points to a role for calcium release from intracellular stores in this process. In this article, we discuss how RyR-mediated calcium release contributes to the activation of the calcium-dependent transcription factor CREB and the subsequent LTP generation. We present novel results from our laboratory showing ERK-mediated CREB activation by hydrogen peroxide. This activation takes place in the absence of extracellular calcium and is blocked by inhibitory ryanodine concentrations, suggesting it is caused by redox activation of RyR-mediated calcium release.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.37 n.4 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400028en10.4067/S0716-97602004000400028
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Calcium signals intracellular stores transcription oxidation neurons skeletal muscle
spellingShingle	Calcium signals intracellular stores transcription oxidation neurons skeletal muscle CARRASCO,MARÍA ANGÉLICA JAIMOVICH,ENRIQUE KEMMERLING,ULRIKE HIDALGO,CECILIA Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
description	Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed only recently. In this tissue, most cytoplasmic and nuclear calcium signals originate from calcium release from internal stores, mediated either by ryanodine receptor (RyR) or IP3 receptor (IP3R) channels. The latter are located both in the sarcoplasmic reticulum (SR) and in the nuclear membrane, and their activation results in long-lasting nuclear calcium increase. The calcium signals mediated by RyR and IP3R are very different in kinetics, amplitude and subcellular localization; an open question is whether these differences are differentially sensed by transcription factors. In neurons, it is well established that calcium entry through L-type calcium channels and NMDA receptors plays a role in the regulation of gene expression. Increasing evidence, however, points to a role for calcium release from intracellular stores in this process. In this article, we discuss how RyR-mediated calcium release contributes to the activation of the calcium-dependent transcription factor CREB and the subsequent LTP generation. We present novel results from our laboratory showing ERK-mediated CREB activation by hydrogen peroxide. This activation takes place in the absence of extracellular calcium and is blocked by inhibitory ryanodine concentrations, suggesting it is caused by redox activation of RyR-mediated calcium release.
author	CARRASCO,MARÍA ANGÉLICA JAIMOVICH,ENRIQUE KEMMERLING,ULRIKE HIDALGO,CECILIA
author_facet	CARRASCO,MARÍA ANGÉLICA JAIMOVICH,ENRIQUE KEMMERLING,ULRIKE HIDALGO,CECILIA
author_sort	CARRASCO,MARÍA ANGÉLICA
title	Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
title_short	Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
title_full	Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
title_fullStr	Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
title_full_unstemmed	Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
title_sort	signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
publisher	Sociedad de Biología de Chile
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400028
work_keys_str_mv	AT carrascomariaangelica signaltransductionandgeneexpressionregulatedbycalciumreleasefrominternalstoresinexcitablecells AT jaimovichenrique signaltransductionandgeneexpressionregulatedbycalciumreleasefrominternalstoresinexcitablecells AT kemmerlingulrike signaltransductionandgeneexpressionregulatedbycalciumreleasefrominternalstoresinexcitablecells AT hidalgocecilia signaltransductionandgeneexpressionregulatedbycalciumreleasefrominternalstoresinexcitablecells
_version_	1718441379450847232

Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells

Ejemplares similares