Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine

This study reports the data recorded from four patients intoxicated with shellfish during the summer 2002, after consuming ribbed mussels (Aulacomya ater) with paralytic shellfish toxin contents of 8,066 ± 61.37 mg/100 gr of tissue. Data associated with clinical variables and paralytic shellfish tox...

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Autores principales: GARCÍA,CARLOS, LAGOS,MARCELO, TRUAN,DOMINIQUE, LATTES,KARINNA, VÉJAR,OMAR, CHAMORRO,BEATRIZ, IGLESIAS,VERÓNICA, ANDRINOLO,DARÍO, LAGOS,NÉSTOR
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2005
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200009
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spelling oai:scielo:S0716-976020050002000092007-01-04Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urineGARCÍA,CARLOSLAGOS,MARCELOTRUAN,DOMINIQUELATTES,KARINNAVÉJAR,OMARCHAMORRO,BEATRIZIGLESIAS,VERÓNICAANDRINOLO,DARÍOLAGOS,NÉSTOR paralytic shellfish poisoning PSP human intoxication Chilean fjords This study reports the data recorded from four patients intoxicated with shellfish during the summer 2002, after consuming ribbed mussels (Aulacomya ater) with paralytic shellfish toxin contents of 8,066 ± 61.37 mg/100 gr of tissue. Data associated with clinical variables and paralytic shellfish toxins analysis in plasma and urine of the intoxicated patients are shown. For this purpose, the evolution of respiratory frequency, arterial blood pressure and heart rate of the poisoned patients were followed and recorded. The clinical treatment to reach a clinically stable condition and return to normal physiological parameters was a combination of hydration with saline solution supplemented with Dobutamine (vasoactive drug), Furosemide (diuretic) and Ranitidine (inhibitor of acid secretion). The physiological condition of patients began to improve after four hours of clinical treatment, and a stable condition was reached between 12 to 24 hours. The HPLC-FLD analysis showed only the GTX3/GTX2 epimers in the blood and urine samples. Also, these epimers were the only paralytic shellfish toxins found in the shellfish extract sampleinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.2-3 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200009en10.4067/S0716-97602005000200009
institution Scielo Chile
collection Scielo Chile
language English
topic paralytic shellfish poisoning
PSP human intoxication
Chilean fjords
spellingShingle paralytic shellfish poisoning
PSP human intoxication
Chilean fjords
GARCÍA,CARLOS
LAGOS,MARCELO
TRUAN,DOMINIQUE
LATTES,KARINNA
VÉJAR,OMAR
CHAMORRO,BEATRIZ
IGLESIAS,VERÓNICA
ANDRINOLO,DARÍO
LAGOS,NÉSTOR
Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine
description This study reports the data recorded from four patients intoxicated with shellfish during the summer 2002, after consuming ribbed mussels (Aulacomya ater) with paralytic shellfish toxin contents of 8,066 ± 61.37 mg/100 gr of tissue. Data associated with clinical variables and paralytic shellfish toxins analysis in plasma and urine of the intoxicated patients are shown. For this purpose, the evolution of respiratory frequency, arterial blood pressure and heart rate of the poisoned patients were followed and recorded. The clinical treatment to reach a clinically stable condition and return to normal physiological parameters was a combination of hydration with saline solution supplemented with Dobutamine (vasoactive drug), Furosemide (diuretic) and Ranitidine (inhibitor of acid secretion). The physiological condition of patients began to improve after four hours of clinical treatment, and a stable condition was reached between 12 to 24 hours. The HPLC-FLD analysis showed only the GTX3/GTX2 epimers in the blood and urine samples. Also, these epimers were the only paralytic shellfish toxins found in the shellfish extract sample
author GARCÍA,CARLOS
LAGOS,MARCELO
TRUAN,DOMINIQUE
LATTES,KARINNA
VÉJAR,OMAR
CHAMORRO,BEATRIZ
IGLESIAS,VERÓNICA
ANDRINOLO,DARÍO
LAGOS,NÉSTOR
author_facet GARCÍA,CARLOS
LAGOS,MARCELO
TRUAN,DOMINIQUE
LATTES,KARINNA
VÉJAR,OMAR
CHAMORRO,BEATRIZ
IGLESIAS,VERÓNICA
ANDRINOLO,DARÍO
LAGOS,NÉSTOR
author_sort GARCÍA,CARLOS
title Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine
title_short Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine
title_full Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine
title_fullStr Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine
title_full_unstemmed Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine
title_sort human intoxication with paralytic shellfish toxins: clinical parameters and toxin analysis in plasma and urine
publisher Sociedad de Biología de Chile
publishDate 2005
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200009
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