Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats

Neuromuscular blocking agents suppress central respiratory activity through their inhibitory effects on preinspiratory neurons and the synaptic drive from preinspiratory neurons to inspiratory neurons. Central CO2-chemosensitive areas, which partly consist of CO2-excited neurons, in the rostral vent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	SAKURABA,SHIGEKI, KUWANA,SHUN-ICHI, ERIKSSON,LARS I, OKADA,YASUMASA, OCHIAI,RYOICHI, KASHIWAGI,MASANORI, HATORI,EIKI, LINDAHL,STEN G. E., TAKEDA,JUNZO
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2005
Materias:	brainstem chemosensitivity CO2 responsiveness muscle relaxant nicotinic acetylcholine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200012
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602005000200012
record_format	dspace
spelling	oai:scielo:S0716-976020050002000122007-01-04Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn ratsSAKURABA,SHIGEKIKUWANA,SHUN-ICHIERIKSSON,LARS IOKADA,YASUMASAOCHIAI,RYOICHIKASHIWAGI,MASANORIHATORI,EIKILINDAHL,STEN G. E.TAKEDA,JUNZO brainstem chemosensitivity CO2 responsiveness muscle relaxant nicotinic acetylcholine Neuromuscular blocking agents suppress central respiratory activity through their inhibitory effects on preinspiratory neurons and the synaptic drive from preinspiratory neurons to inspiratory neurons. Central CO2-chemosensitive areas, which partly consist of CO2-excited neurons, in the rostral ventrolateral medulla are thought to provide tonic drive to the central respiratory network and involve cholinergic mechanisms, which led us to hypothesize that neuromuscular blocking agents can inhibit CO2-excited neurons and attenuate respiratory CO2 responsiveness. To test this hypothesis, we used isolated brainstem-spinal cord preparations from newborn rats. The increase of C4 burst frequency induced by a hypercapnic superfusate, i.e. respiratory CO2 responsiveness, was suppressed by the application of neuromuscular blocking agents, either d-tubocurarine (10, 100μM) or vecuronium (100μM). These agents (40μM) also induced hyperpolarization and decreases in firing frequency of CO2-excited neurons in the rostral ventrolateral medulla. Our results demonstrate that neuromuscular blocking agents inhibit CO2-excited tonic firing neurons and attenuate respiratory CO2 responsiveness.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.2-3 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200012en10.4067/S0716-97602005000200012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	brainstem chemosensitivity CO2 responsiveness muscle relaxant nicotinic acetylcholine
spellingShingle	brainstem chemosensitivity CO2 responsiveness muscle relaxant nicotinic acetylcholine SAKURABA,SHIGEKI KUWANA,SHUN-ICHI ERIKSSON,LARS I OKADA,YASUMASA OCHIAI,RYOICHI KASHIWAGI,MASANORI HATORI,EIKI LINDAHL,STEN G. E. TAKEDA,JUNZO Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
description	Neuromuscular blocking agents suppress central respiratory activity through their inhibitory effects on preinspiratory neurons and the synaptic drive from preinspiratory neurons to inspiratory neurons. Central CO2-chemosensitive areas, which partly consist of CO2-excited neurons, in the rostral ventrolateral medulla are thought to provide tonic drive to the central respiratory network and involve cholinergic mechanisms, which led us to hypothesize that neuromuscular blocking agents can inhibit CO2-excited neurons and attenuate respiratory CO2 responsiveness. To test this hypothesis, we used isolated brainstem-spinal cord preparations from newborn rats. The increase of C4 burst frequency induced by a hypercapnic superfusate, i.e. respiratory CO2 responsiveness, was suppressed by the application of neuromuscular blocking agents, either d-tubocurarine (10, 100μM) or vecuronium (100μM). These agents (40μM) also induced hyperpolarization and decreases in firing frequency of CO2-excited neurons in the rostral ventrolateral medulla. Our results demonstrate that neuromuscular blocking agents inhibit CO2-excited tonic firing neurons and attenuate respiratory CO2 responsiveness.
author	SAKURABA,SHIGEKI KUWANA,SHUN-ICHI ERIKSSON,LARS I OKADA,YASUMASA OCHIAI,RYOICHI KASHIWAGI,MASANORI HATORI,EIKI LINDAHL,STEN G. E. TAKEDA,JUNZO
author_facet	SAKURABA,SHIGEKI KUWANA,SHUN-ICHI ERIKSSON,LARS I OKADA,YASUMASA OCHIAI,RYOICHI KASHIWAGI,MASANORI HATORI,EIKI LINDAHL,STEN G. E. TAKEDA,JUNZO
author_sort	SAKURABA,SHIGEKI
title	Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
title_short	Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
title_full	Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
title_fullStr	Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
title_full_unstemmed	Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
title_sort	effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
publisher	Sociedad de Biología de Chile
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200012
work_keys_str_mv	AT sakurabashigeki effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT kuwanashunichi effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT erikssonlarsi effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT okadayasumasa effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT ochiairyoichi effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT kashiwagimasanori effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT hatorieiki effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT lindahlstenge effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats AT takedajunzo effectsofneuromuscularblockingagentsoncentralrespiratorychemosensitivityinnewbornrats
_version_	1718441388591284224

Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats

Ejemplares similares