Tissue mRNA expression in rat of newly described matrix metalloproteinases

Matrix metalloproteinases (MMPs) comprise a large group of endoproteinases that degrade all protein components of the extracellular matrix. Functionally, MMPs contribute to several different physiological as well as pathological conditions. The number of newly described MMPs has increased in recent...

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Autores principales:	BERNAL,FABIÁN, HARTUNG,HANS-PETER, KIESEIER,BERND C
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2005
Materias:	bone CNS epilysin kidney MT5-MMP MT6-MMP testis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200016
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spelling	oai:scielo:S0716-976020050002000162007-01-04Tissue mRNA expression in rat of newly described matrix metalloproteinasesBERNAL,FABIÁNHARTUNG,HANS-PETERKIESEIER,BERND C bone CNS epilysin kidney MT5-MMP MT6-MMP testis Matrix metalloproteinases (MMPs) comprise a large group of endoproteinases that degrade all protein components of the extracellular matrix. Functionally, MMPs contribute to several different physiological as well as pathological conditions. The number of newly described MMPs has increased in recent years, although current knowledge about their expression pattern in various tissues remains incomplete. Here we analyzed the relative mRNA expression of the most recently described MMPs _ MT5-MMP (MMP-24), MT6-MMP (MMP-25), MMP-27 and epilysin (MMP-28) _ in a broad selection of rat tissues using real time-PCR. MMP-24 mRNA was found to be widely expressed with predominance in the central nervous system. MMP-25 mRNA, in contrast, exhibited peak expression levels in testis, kidney and skeletal muscle, differing from previously described distribution patterns in humans. mRNAs for MMP-27 and MMP-28 were generally expressed at a lower level. All four MMPs studied were detected at higher mRNA levels in bone and kidney, suggesting a possible role of these MMPs in physiological processes within these two organs. The present study highlights the differential distribution pattern of newly described MMPs among different tissues and underlines differences in the mRNA expression between different species.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.2-3 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200016en10.4067/S0716-97602005000200016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	bone CNS epilysin kidney MT5-MMP MT6-MMP testis
spellingShingle	bone CNS epilysin kidney MT5-MMP MT6-MMP testis BERNAL,FABIÁN HARTUNG,HANS-PETER KIESEIER,BERND C Tissue mRNA expression in rat of newly described matrix metalloproteinases
description	Matrix metalloproteinases (MMPs) comprise a large group of endoproteinases that degrade all protein components of the extracellular matrix. Functionally, MMPs contribute to several different physiological as well as pathological conditions. The number of newly described MMPs has increased in recent years, although current knowledge about their expression pattern in various tissues remains incomplete. Here we analyzed the relative mRNA expression of the most recently described MMPs _ MT5-MMP (MMP-24), MT6-MMP (MMP-25), MMP-27 and epilysin (MMP-28) _ in a broad selection of rat tissues using real time-PCR. MMP-24 mRNA was found to be widely expressed with predominance in the central nervous system. MMP-25 mRNA, in contrast, exhibited peak expression levels in testis, kidney and skeletal muscle, differing from previously described distribution patterns in humans. mRNAs for MMP-27 and MMP-28 were generally expressed at a lower level. All four MMPs studied were detected at higher mRNA levels in bone and kidney, suggesting a possible role of these MMPs in physiological processes within these two organs. The present study highlights the differential distribution pattern of newly described MMPs among different tissues and underlines differences in the mRNA expression between different species.
author	BERNAL,FABIÁN HARTUNG,HANS-PETER KIESEIER,BERND C
author_facet	BERNAL,FABIÁN HARTUNG,HANS-PETER KIESEIER,BERND C
author_sort	BERNAL,FABIÁN
title	Tissue mRNA expression in rat of newly described matrix metalloproteinases
title_short	Tissue mRNA expression in rat of newly described matrix metalloproteinases
title_full	Tissue mRNA expression in rat of newly described matrix metalloproteinases
title_fullStr	Tissue mRNA expression in rat of newly described matrix metalloproteinases
title_full_unstemmed	Tissue mRNA expression in rat of newly described matrix metalloproteinases
title_sort	tissue mrna expression in rat of newly described matrix metalloproteinases
publisher	Sociedad de Biología de Chile
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200016
work_keys_str_mv	AT bernalfabian tissuemrnaexpressioninratofnewlydescribedmatrixmetalloproteinases AT hartunghanspeter tissuemrnaexpressioninratofnewlydescribedmatrixmetalloproteinases AT kieseierberndc tissuemrnaexpressioninratofnewlydescribedmatrixmetalloproteinases
_version_	1718441389473136640

Tissue mRNA expression in rat of newly described matrix metalloproteinases

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