Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies

Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105...

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Autores principales:	LINHARES,JOSÉ JUVENAL, GUERREIRO DA SILVA,ISMAEL DALE COTRIM, NOGUEIRA DE SOUZA,NAIARA C, COELHO NORONHA,EMMANUELLE, FERRARO,ODAIR, DE CARVALHO,CRISTINA VALLETA, CHADA BARACAT,EDMUND, FARAH BARACAT,FAUSTO
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2005
Materias:	Breast cancer genetic polymorphisms GSTM1
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200017
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spelling	oai:scielo:S0716-976020050002000172007-01-04Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologiesLINHARES,JOSÉ JUVENALGUERREIRO DA SILVA,ISMAEL DALE COTRIMNOGUEIRA DE SOUZA,NAIARA CCOELHO NORONHA,EMMANUELLEFERRARO,ODAIRDE CARVALHO,CRISTINA VALLETACHADA BARACAT,EDMUNDFARAH BARACAT,FAUSTO Breast cancer genetic polymorphisms GSTM1 Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX® kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X² or Fisher's exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that singlegene GSTM1 polymorphisms do not confer a substantial risk of breastcancer to its carriers. Furthermore, in this study no correlation was found between GSTs andsmoking, reproductive history and several clinical pathologies with respect to cancer risk.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.2-3 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200017en10.4067/S0716-97602005000200017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Breast cancer genetic polymorphisms GSTM1
spellingShingle	Breast cancer genetic polymorphisms GSTM1 LINHARES,JOSÉ JUVENAL GUERREIRO DA SILVA,ISMAEL DALE COTRIM NOGUEIRA DE SOUZA,NAIARA C COELHO NORONHA,EMMANUELLE FERRARO,ODAIR DE CARVALHO,CRISTINA VALLETA CHADA BARACAT,EDMUND FARAH BARACAT,FAUSTO Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
description	Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX® kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X² or Fisher's exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that singlegene GSTM1 polymorphisms do not confer a substantial risk of breastcancer to its carriers. Furthermore, in this study no correlation was found between GSTs andsmoking, reproductive history and several clinical pathologies with respect to cancer risk.
author	LINHARES,JOSÉ JUVENAL GUERREIRO DA SILVA,ISMAEL DALE COTRIM NOGUEIRA DE SOUZA,NAIARA C COELHO NORONHA,EMMANUELLE FERRARO,ODAIR DE CARVALHO,CRISTINA VALLETA CHADA BARACAT,EDMUND FARAH BARACAT,FAUSTO
author_facet	LINHARES,JOSÉ JUVENAL GUERREIRO DA SILVA,ISMAEL DALE COTRIM NOGUEIRA DE SOUZA,NAIARA C COELHO NORONHA,EMMANUELLE FERRARO,ODAIR DE CARVALHO,CRISTINA VALLETA CHADA BARACAT,EDMUND FARAH BARACAT,FAUSTO
author_sort	LINHARES,JOSÉ JUVENAL
title	Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
title_short	Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
title_full	Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
title_fullStr	Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
title_full_unstemmed	Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
title_sort	genetic polymorphism of gstm1 in women with breast cancer and interact with reproductive history and several clinical pathologies
publisher	Sociedad de Biología de Chile
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200017
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Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies

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