How the carotid body works: Different strategies and preparations to solve different problems

This is a review of the different experimental approaches developed to solve the problems in our progress towards a comprehensive understanding of how arterial chemoreceptors operate. An analysis is performed of the bases, advantages and limits of the following preparations: studies of ventilatory r...

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Autores principales:	ZAPATA,PATRICIO, LARRAÍN,CAROLINA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2005
Materias:	arterial chemoreceptors carotid body chemosensory activity co-cultures cultures in situ in vitro petrosal ganglia superfusion
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400002
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spelling	oai:scielo:S0716-976020050004000022006-04-18How the carotid body works: Different strategies and preparations to solve different problemsZAPATA,PATRICIOLARRAÍN,CAROLINA arterial chemoreceptors carotid body chemosensory activity co-cultures cultures in situ in vitro petrosal ganglia superfusion This is a review of the different experimental approaches developed to solve the problems in our progress towards a comprehensive understanding of how arterial chemoreceptors operate. An analysis is performed of the bases, advantages and limits of the following preparations: studies of ventilatory reflexes originated from carotid bodies (CBs) in the entire animal; recordings of CB chemosensory discharges in situ; CB preparations perfused in situ; CB explants in oculo; CB explants in ovo; CB preparations incubated in vitro; CB preparations superfused in vitro; CB preparations perfused and superfused in vitro; CB tissue slices in vitro; cells acutely dissociated from CBs; CB cells in tissue culture; petrosal ganglia superfused in vitro; petrosal ganglion cells in tissue culture; and co-cultures of CB and sensory ganglion cells. A brief historical account is given of the passage from one preparation to the next one. Emphasis is placed on personal experience with the different preparations whenever possible. Examples are given of the importance of selecting the appropriate experimental preparation for solving each particular theoretical problem. In fact, brilliant ideas on how the CB works have been unproductive until finding the adequate experimental approach to explore the validity of such ideas.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.4 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400002en10.4067/S0716-97602005000400002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	arterial chemoreceptors carotid body chemosensory activity co-cultures cultures in situ in vitro petrosal ganglia superfusion
spellingShingle	arterial chemoreceptors carotid body chemosensory activity co-cultures cultures in situ in vitro petrosal ganglia superfusion ZAPATA,PATRICIO LARRAÍN,CAROLINA How the carotid body works: Different strategies and preparations to solve different problems
description	This is a review of the different experimental approaches developed to solve the problems in our progress towards a comprehensive understanding of how arterial chemoreceptors operate. An analysis is performed of the bases, advantages and limits of the following preparations: studies of ventilatory reflexes originated from carotid bodies (CBs) in the entire animal; recordings of CB chemosensory discharges in situ; CB preparations perfused in situ; CB explants in oculo; CB explants in ovo; CB preparations incubated in vitro; CB preparations superfused in vitro; CB preparations perfused and superfused in vitro; CB tissue slices in vitro; cells acutely dissociated from CBs; CB cells in tissue culture; petrosal ganglia superfused in vitro; petrosal ganglion cells in tissue culture; and co-cultures of CB and sensory ganglion cells. A brief historical account is given of the passage from one preparation to the next one. Emphasis is placed on personal experience with the different preparations whenever possible. Examples are given of the importance of selecting the appropriate experimental preparation for solving each particular theoretical problem. In fact, brilliant ideas on how the CB works have been unproductive until finding the adequate experimental approach to explore the validity of such ideas.
author	ZAPATA,PATRICIO LARRAÍN,CAROLINA
author_facet	ZAPATA,PATRICIO LARRAÍN,CAROLINA
author_sort	ZAPATA,PATRICIO
title	How the carotid body works: Different strategies and preparations to solve different problems
title_short	How the carotid body works: Different strategies and preparations to solve different problems
title_full	How the carotid body works: Different strategies and preparations to solve different problems
title_fullStr	How the carotid body works: Different strategies and preparations to solve different problems
title_full_unstemmed	How the carotid body works: Different strategies and preparations to solve different problems
title_sort	how the carotid body works: different strategies and preparations to solve different problems
publisher	Sociedad de Biología de Chile
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400002
work_keys_str_mv	AT zapatapatricio howthecarotidbodyworksdifferentstrategiesandpreparationstosolvedifferentproblems AT larraincarolina howthecarotidbodyworksdifferentstrategiesandpreparationstosolvedifferentproblems
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How the carotid body works: Different strategies and preparations to solve different problems

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