Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation

Research on Alzheimer's disease (AD) focuses mainly on neuronal death and synaptic impairment induced by β-Amyloid peptide (Aβ), events at least partially mediated by astrocyte and microglia activation. However, substantial white matter damage and its consequences on brain fun...

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Autores principales:	ROTH,ALEJANDRO D, RAMÍREZ,GIGLIOLA, ALARCÓN,RODRIGO, VON BERNHARDI,ROMMY
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2005
Materias:	cell death glial cells pro-inflammatory cytokines
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400011
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spelling	oai:scielo:S0716-976020050004000112006-04-18Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammationROTH,ALEJANDRO DRAMÍREZ,GIGLIOLAALARCÓN,RODRIGOVON BERNHARDI,ROMMY cell death glial cells pro-inflammatory cytokines Research on Alzheimer's disease (AD) focuses mainly on neuronal death and synaptic impairment induced by β-Amyloid peptide (Aβ), events at least partially mediated by astrocyte and microglia activation. However, substantial white matter damage and its consequences on brain function warrant the study of oligodendrocytes participation in the pathogenesis and progression of AD. Here, we analyze reports on oligodendrocytes' compromise in AD and discuss some experimental data indicative of Aβ toxicity in culture. We observed that 1 μM of fibrilogenic Aβ peptide damages oligodendrocytes in vitro; while pro-inflammatory molecules (1 μg/ml LPS + 1 ng/ml IFNγ) or the presence of astrocytes reduced the Ab-induced damage. This agrees with our previous results showing an astrocyte-mediated protective effect over Aβ-induced damage on hippocampal cells and modulation of the activation of microglial cells in culture. Oligodendrocytes protection by astrocytes could be, either by reduction of Aβ fibrilogenesis/deposition or prevention of oxidative damage. Likewise, the decrease of Aβ-induced damage by proinflammatory molecules could reflect the production of trophic factors by activated oligodendrocytes and/or a metabolic activation as observed during myelination. Considering the association of inflammation with neurodegenerative diseases, oligodendrocytes impairment in AD patients could potentiate cell damage under pathological conditions.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.4 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400011en10.4067/S0716-97602005000400011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	cell death glial cells pro-inflammatory cytokines
spellingShingle	cell death glial cells pro-inflammatory cytokines ROTH,ALEJANDRO D RAMÍREZ,GIGLIOLA ALARCÓN,RODRIGO VON BERNHARDI,ROMMY Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
description	Research on Alzheimer's disease (AD) focuses mainly on neuronal death and synaptic impairment induced by β-Amyloid peptide (Aβ), events at least partially mediated by astrocyte and microglia activation. However, substantial white matter damage and its consequences on brain function warrant the study of oligodendrocytes participation in the pathogenesis and progression of AD. Here, we analyze reports on oligodendrocytes' compromise in AD and discuss some experimental data indicative of Aβ toxicity in culture. We observed that 1 μM of fibrilogenic Aβ peptide damages oligodendrocytes in vitro; while pro-inflammatory molecules (1 μg/ml LPS + 1 ng/ml IFNγ) or the presence of astrocytes reduced the Ab-induced damage. This agrees with our previous results showing an astrocyte-mediated protective effect over Aβ-induced damage on hippocampal cells and modulation of the activation of microglial cells in culture. Oligodendrocytes protection by astrocytes could be, either by reduction of Aβ fibrilogenesis/deposition or prevention of oxidative damage. Likewise, the decrease of Aβ-induced damage by proinflammatory molecules could reflect the production of trophic factors by activated oligodendrocytes and/or a metabolic activation as observed during myelination. Considering the association of inflammation with neurodegenerative diseases, oligodendrocytes impairment in AD patients could potentiate cell damage under pathological conditions.
author	ROTH,ALEJANDRO D RAMÍREZ,GIGLIOLA ALARCÓN,RODRIGO VON BERNHARDI,ROMMY
author_facet	ROTH,ALEJANDRO D RAMÍREZ,GIGLIOLA ALARCÓN,RODRIGO VON BERNHARDI,ROMMY
author_sort	ROTH,ALEJANDRO D
title	Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
title_short	Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
title_full	Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
title_fullStr	Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
title_full_unstemmed	Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
title_sort	oligodendrocytes damage in alzheimer's disease: beta amyloid toxicity and inflammation
publisher	Sociedad de Biología de Chile
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400011
work_keys_str_mv	AT rothalejandrod oligodendrocytesdamageinalzheimersdiseasebetaamyloidtoxicityandinflammation AT ramirezgigliola oligodendrocytesdamageinalzheimersdiseasebetaamyloidtoxicityandinflammation AT alarconrodrigo oligodendrocytesdamageinalzheimersdiseasebetaamyloidtoxicityandinflammation AT vonbernhardirommy oligodendrocytesdamageinalzheimersdiseasebetaamyloidtoxicityandinflammation
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Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation

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