Compensatory responses induced by oxidative stress in Alzheimer disease

Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-β deposition and hyperphosphorylated tau function as...

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Autores principales:	MOREIRA,PAULA I, ZHU,XIONGWEI, LIU,QUAN, HONDA,KAZUHIRO, SIEDLAK,SANDRA L, HARRIS,PEGGY L, SMITH,MARK A., PERRY,GEORGE
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	Alzheimer disease antioxidant therapy mitochondria oxidative stress redox metals
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100002
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spelling	oai:scielo:S0716-976020060001000022006-06-30Compensatory responses induced by oxidative stress in Alzheimer diseaseMOREIRA,PAULA IZHU,XIONGWEILIU,QUANHONDA,KAZUHIROSIEDLAK,SANDRA LHARRIS,PEGGY LSMITH,MARK A.PERRY,GEORGE Alzheimer disease antioxidant therapy mitochondria oxidative stress redox metals Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-β deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100002en10.4067/S0716-97602006000100002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Alzheimer disease antioxidant therapy mitochondria oxidative stress redox metals
spellingShingle	Alzheimer disease antioxidant therapy mitochondria oxidative stress redox metals MOREIRA,PAULA I ZHU,XIONGWEI LIU,QUAN HONDA,KAZUHIRO SIEDLAK,SANDRA L HARRIS,PEGGY L SMITH,MARK A. PERRY,GEORGE Compensatory responses induced by oxidative stress in Alzheimer disease
description	Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-β deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.
author	MOREIRA,PAULA I ZHU,XIONGWEI LIU,QUAN HONDA,KAZUHIRO SIEDLAK,SANDRA L HARRIS,PEGGY L SMITH,MARK A. PERRY,GEORGE
author_facet	MOREIRA,PAULA I ZHU,XIONGWEI LIU,QUAN HONDA,KAZUHIRO SIEDLAK,SANDRA L HARRIS,PEGGY L SMITH,MARK A. PERRY,GEORGE
author_sort	MOREIRA,PAULA I
title	Compensatory responses induced by oxidative stress in Alzheimer disease
title_short	Compensatory responses induced by oxidative stress in Alzheimer disease
title_full	Compensatory responses induced by oxidative stress in Alzheimer disease
title_fullStr	Compensatory responses induced by oxidative stress in Alzheimer disease
title_full_unstemmed	Compensatory responses induced by oxidative stress in Alzheimer disease
title_sort	compensatory responses induced by oxidative stress in alzheimer disease
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100002
work_keys_str_mv	AT moreirapaulai compensatoryresponsesinducedbyoxidativestressinalzheimerdisease AT zhuxiongwei compensatoryresponsesinducedbyoxidativestressinalzheimerdisease AT liuquan compensatoryresponsesinducedbyoxidativestressinalzheimerdisease AT hondakazuhiro compensatoryresponsesinducedbyoxidativestressinalzheimerdisease AT siedlaksandral compensatoryresponsesinducedbyoxidativestressinalzheimerdisease AT harrispeggyl compensatoryresponsesinducedbyoxidativestressinalzheimerdisease AT smithmarka compensatoryresponsesinducedbyoxidativestressinalzheimerdisease AT perrygeorge compensatoryresponsesinducedbyoxidativestressinalzheimerdisease
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Compensatory responses induced by oxidative stress in Alzheimer disease

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