Iron homeostasis in the lung
Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposure to the atmosphere results in significant exposu...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad de Biología de Chile
2006
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100008 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0716-97602006000100008 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0716-976020060001000082006-06-30Iron homeostasis in the lungGHIO,ANDREW JTURI,JENNIFER LYANG,FUNMEIGARRICK,LAURA MGARRICK,MICHAEL D Lung diseases oxidative stress SLC11A2 protein SLC40A1 protein Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposure to the atmosphere results in significant exposure of the lungs to catalytically active iron. The lungs have a mechanism for detoxification to prevent associated generation of oxidative stress. Those same proteins that participate in iron uptake in the gut are also employed in the lung to transport iron intracellularly and sequester it in an inactive form within ferritin. The release of metal is expedited (as transferrin and ferritin) from lung tissue to the respiratory lining fluid for clearance by the mucocilliary pathway or to the reticuloendothelial system for long-term storage. This pathway is likely to be the major method for the control of oxidative stress presented to the respiratory tract.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100008en10.4067/S0716-97602006000100008 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Lung diseases oxidative stress SLC11A2 protein SLC40A1 protein |
| spellingShingle |
Lung diseases oxidative stress SLC11A2 protein SLC40A1 protein GHIO,ANDREW J TURI,JENNIFER L YANG,FUNMEI GARRICK,LAURA M GARRICK,MICHAEL D Iron homeostasis in the lung |
| description |
Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposure to the atmosphere results in significant exposure of the lungs to catalytically active iron. The lungs have a mechanism for detoxification to prevent associated generation of oxidative stress. Those same proteins that participate in iron uptake in the gut are also employed in the lung to transport iron intracellularly and sequester it in an inactive form within ferritin. The release of metal is expedited (as transferrin and ferritin) from lung tissue to the respiratory lining fluid for clearance by the mucocilliary pathway or to the reticuloendothelial system for long-term storage. This pathway is likely to be the major method for the control of oxidative stress presented to the respiratory tract. |
| author |
GHIO,ANDREW J TURI,JENNIFER L YANG,FUNMEI GARRICK,LAURA M GARRICK,MICHAEL D |
| author_facet |
GHIO,ANDREW J TURI,JENNIFER L YANG,FUNMEI GARRICK,LAURA M GARRICK,MICHAEL D |
| author_sort |
GHIO,ANDREW J |
| title |
Iron homeostasis in the lung |
| title_short |
Iron homeostasis in the lung |
| title_full |
Iron homeostasis in the lung |
| title_fullStr |
Iron homeostasis in the lung |
| title_full_unstemmed |
Iron homeostasis in the lung |
| title_sort |
iron homeostasis in the lung |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2006 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100008 |
| work_keys_str_mv |
AT ghioandrewj ironhomeostasisinthelung AT turijenniferl ironhomeostasisinthelung AT yangfunmei ironhomeostasisinthelung AT garricklauram ironhomeostasisinthelung AT garrickmichaeld ironhomeostasisinthelung |
| _version_ |
1718441395072532480 |