Inhibition of iron and copper uptake by iron, copper and zinc

Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar chemical characteristics and uptake process can take place. The consequences of these in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: ARREDONDO,MIGUEL, MARTÍNEZ,RONNY, NÚÑEZ,MARCO T, RUZ,MANUEL, OLIVARES,MANUEL
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2006
Materias:
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100011
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0716-97602006000100011
record_format dspace
spelling oai:scielo:S0716-976020060001000112006-06-30Inhibition of iron and copper uptake by iron, copper and zincARREDONDO,MIGUELMARTÍNEZ,RONNYNÚÑEZ,MARCO TRUZ,MANUELOLIVARES,MANUEL competition interaction metals uptake Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar chemical characteristics and uptake process can take place. The consequences of these interactions may depend on the relative concentrations of the nutrients. In this work, we measure the effects of increasing concentrations of iron, zinc, and copper on iron and copper uptake in Caco-2 cells. Intracellular Fe or Cu levels were affected by incubating with increased concentrations of metals. However, when the cells already had different intracellular metal concentration, the uptake of Fe or Cu was nor affected. In competition studies, we showed that Cu and Zn inhibited Fe uptake, and while Fe inhibited Cu uptake, Zn did not. When the three metals were given together (1: 1: 1 ratio), Fe or Cu uptake was inhibited ~40%. These results point to a potential risk in the absorption and bioavailability of these minerals by the presence of other minerals in the diet. This aspect must be considered in food supplementation and fortification programs.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100011en10.4067/S0716-97602006000100011
institution Scielo Chile
collection Scielo Chile
language English
topic competition
interaction
metals
uptake
spellingShingle competition
interaction
metals
uptake
ARREDONDO,MIGUEL
MARTÍNEZ,RONNY
NÚÑEZ,MARCO T
RUZ,MANUEL
OLIVARES,MANUEL
Inhibition of iron and copper uptake by iron, copper and zinc
description Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar chemical characteristics and uptake process can take place. The consequences of these interactions may depend on the relative concentrations of the nutrients. In this work, we measure the effects of increasing concentrations of iron, zinc, and copper on iron and copper uptake in Caco-2 cells. Intracellular Fe or Cu levels were affected by incubating with increased concentrations of metals. However, when the cells already had different intracellular metal concentration, the uptake of Fe or Cu was nor affected. In competition studies, we showed that Cu and Zn inhibited Fe uptake, and while Fe inhibited Cu uptake, Zn did not. When the three metals were given together (1: 1: 1 ratio), Fe or Cu uptake was inhibited ~40%. These results point to a potential risk in the absorption and bioavailability of these minerals by the presence of other minerals in the diet. This aspect must be considered in food supplementation and fortification programs.
author ARREDONDO,MIGUEL
MARTÍNEZ,RONNY
NÚÑEZ,MARCO T
RUZ,MANUEL
OLIVARES,MANUEL
author_facet ARREDONDO,MIGUEL
MARTÍNEZ,RONNY
NÚÑEZ,MARCO T
RUZ,MANUEL
OLIVARES,MANUEL
author_sort ARREDONDO,MIGUEL
title Inhibition of iron and copper uptake by iron, copper and zinc
title_short Inhibition of iron and copper uptake by iron, copper and zinc
title_full Inhibition of iron and copper uptake by iron, copper and zinc
title_fullStr Inhibition of iron and copper uptake by iron, copper and zinc
title_full_unstemmed Inhibition of iron and copper uptake by iron, copper and zinc
title_sort inhibition of iron and copper uptake by iron, copper and zinc
publisher Sociedad de Biología de Chile
publishDate 2006
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100011
work_keys_str_mv AT arredondomiguel inhibitionofironandcopperuptakebyironcopperandzinc
AT martinezronny inhibitionofironandcopperuptakebyironcopperandzinc
AT nunezmarcot inhibitionofironandcopperuptakebyironcopperandzinc
AT ruzmanuel inhibitionofironandcopperuptakebyironcopperandzinc
AT olivaresmanuel inhibitionofironandcopperuptakebyironcopperandzinc
_version_ 1718441395752009728