Iron and glutathione at the crossroad of redox metabolism in neurons

Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here,...

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Autores principales:	ARACENA,PAULA, AGUIRRE,PABLA, MUÑOZ,PABLO, NÚÑEZ,MARCO T
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	neurons iron metabolism iron accumulation oxidative stress glutathione metabolism neurodegeneration
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017
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spelling	oai:scielo:S0716-976020060001000172006-06-30Iron and glutathione at the crossroad of redox metabolism in neuronsARACENA,PAULAAGUIRRE,PABLAMUÑOZ,PABLONÚÑEZ,MARCO T neurons iron metabolism iron accumulation oxidative stress glutathione metabolism neurodegeneration Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017en10.4067/S0716-97602006000100017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	neurons iron metabolism iron accumulation oxidative stress glutathione metabolism neurodegeneration
spellingShingle	neurons iron metabolism iron accumulation oxidative stress glutathione metabolism neurodegeneration ARACENA,PAULA AGUIRRE,PABLA MUÑOZ,PABLO NÚÑEZ,MARCO T Iron and glutathione at the crossroad of redox metabolism in neurons
description	Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death.
author	ARACENA,PAULA AGUIRRE,PABLA MUÑOZ,PABLO NÚÑEZ,MARCO T
author_facet	ARACENA,PAULA AGUIRRE,PABLA MUÑOZ,PABLO NÚÑEZ,MARCO T
author_sort	ARACENA,PAULA
title	Iron and glutathione at the crossroad of redox metabolism in neurons
title_short	Iron and glutathione at the crossroad of redox metabolism in neurons
title_full	Iron and glutathione at the crossroad of redox metabolism in neurons
title_fullStr	Iron and glutathione at the crossroad of redox metabolism in neurons
title_full_unstemmed	Iron and glutathione at the crossroad of redox metabolism in neurons
title_sort	iron and glutathione at the crossroad of redox metabolism in neurons
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017
work_keys_str_mv	AT aracenapaula ironandglutathioneatthecrossroadofredoxmetabolisminneurons AT aguirrepabla ironandglutathioneatthecrossroadofredoxmetabolisminneurons AT munozpablo ironandglutathioneatthecrossroadofredoxmetabolisminneurons AT nunezmarcot ironandglutathioneatthecrossroadofredoxmetabolisminneurons
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Iron and glutathione at the crossroad of redox metabolism in neurons

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