Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies

Bioiron _ central to respiration, photosynthesis and DNA synthesis and complicated by radical chemistry with oxygen _ depends on ferritin, the super family of protein nanocages (maxi-ferritins in humans, animals, plants and bacteria, and mini-ferritins, also called DPS proteins, in bacteria) for iro...

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Autores principales:	LIU,X, HINTZE,K, LONNERDAL,B, THEIL,EC
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100018
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spelling	oai:scielo:S0716-976020060001000182006-06-30Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategiesLIU,XHINTZE,KLONNERDAL,BTHEIL,ECBioiron _ central to respiration, photosynthesis and DNA synthesis and complicated by radical chemistry with oxygen _ depends on ferritin, the super family of protein nanocages (maxi-ferritins in humans, animals, plants and bacteria, and mini-ferritins, also called DPS proteins, in bacteria) for iron and oxygen control. Regulation of ferritin synthesis, best studied in animals, uses DNA transcription and mRNA translation check points. Ferritin is a member of both the "oxidant stress response" gene family that includes thioredoxin reductase and quinine reductase, and a member of the iron responsive gene family that includes ferroportin and mt-aconitase ferritin DNA regulation responds preferentially to oxidant response inducers and ferritin mRNA to iron inducers; heme confers regulator synergy. Ferritin proteins manage iron and oxygen, with ferroxidase sites and iron + oxygen substrates to form mineral of both Fe and O atoms; maxi-ferritins contribute more to cellular iron metabolism and mini-ferritins to stress responses. Iron recovery from ferritin is controlled by gated protein pores, possibly contributing to iron absorption from ferritin, a significant dietary iron source. Ferritin gene regulation is a model for integrating DNA/mRNA controls, while ferritin protein function is central to molecular nutrition cellular metabolism at the crossroads of iron and oxygen in biologyinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100018en10.4067/S0716-97602006000100018
institution	Scielo Chile
collection	Scielo Chile
language	English
description	Bioiron _ central to respiration, photosynthesis and DNA synthesis and complicated by radical chemistry with oxygen _ depends on ferritin, the super family of protein nanocages (maxi-ferritins in humans, animals, plants and bacteria, and mini-ferritins, also called DPS proteins, in bacteria) for iron and oxygen control. Regulation of ferritin synthesis, best studied in animals, uses DNA transcription and mRNA translation check points. Ferritin is a member of both the "oxidant stress response" gene family that includes thioredoxin reductase and quinine reductase, and a member of the iron responsive gene family that includes ferroportin and mt-aconitase ferritin DNA regulation responds preferentially to oxidant response inducers and ferritin mRNA to iron inducers; heme confers regulator synergy. Ferritin proteins manage iron and oxygen, with ferroxidase sites and iron + oxygen substrates to form mineral of both Fe and O atoms; maxi-ferritins contribute more to cellular iron metabolism and mini-ferritins to stress responses. Iron recovery from ferritin is controlled by gated protein pores, possibly contributing to iron absorption from ferritin, a significant dietary iron source. Ferritin gene regulation is a model for integrating DNA/mRNA controls, while ferritin protein function is central to molecular nutrition cellular metabolism at the crossroads of iron and oxygen in biology
author	LIU,X HINTZE,K LONNERDAL,B THEIL,EC
spellingShingle	LIU,X HINTZE,K LONNERDAL,B THEIL,EC Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
author_facet	LIU,X HINTZE,K LONNERDAL,B THEIL,EC
author_sort	LIU,X
title	Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
title_short	Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
title_full	Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
title_fullStr	Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
title_full_unstemmed	Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
title_sort	iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100018
work_keys_str_mv	AT liux ironatthecenterofferritinmetaloxygenhomeostasisandnoveldietarystrategies AT hintzek ironatthecenterofferritinmetaloxygenhomeostasisandnoveldietarystrategies AT lonnerdalb ironatthecenterofferritinmetaloxygenhomeostasisandnoveldietarystrategies AT theilec ironatthecenterofferritinmetaloxygenhomeostasisandnoveldietarystrategies
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Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies

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