Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc

Based on indirect evidence, a role for synaptically released copper and zinc as modulators of neuronal activity has been proposed. To test this proposal directly, we studied the effect of copper, zinc, and other divalent cations on voltage-dependent currents in dissociated toad olfactory neurons and...

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Autores principales:	DELGADO,RICARDO, VERGARA,CECILIA, WOLFF,DANIEL
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	copper zinc modulators channels neuronal excitability
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100019
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spelling	oai:scielo:S0716-976020060001000192006-06-30Divalent cations as modulators of neuronal excitability: Emphasis on copper and zincDELGADO,RICARDOVERGARA,CECILIAWOLFF,DANIEL copper zinc modulators channels neuronal excitability Based on indirect evidence, a role for synaptically released copper and zinc as modulators of neuronal activity has been proposed. To test this proposal directly, we studied the effect of copper, zinc, and other divalent cations on voltage-dependent currents in dissociated toad olfactory neurons and on their firing rate induced by small depolarizing currents. Divalent cations in the nanomolar range sped up the activation kinetics and increased the amplitude of the inward sodium current. In the micromolar range, they caused a dose dependent inhibition of the inward Na+ and Ca2+ currents (I Na and I Ca) and reduced de amplitude of the Ca2+-dependent K+ outward current (I Ca-K). On the other hand, the firing rate of olfactory neurons increased when exposed to nanomolar concentration of divalent cations and decreased when exposed to micromolar concentrations. This biphasic effect of divalent cations on neuronal excitability may be explained by the interaction of these ions with high and low affinity sites in voltage-gated channels. Our results support the idea that these ions are normal modulators of neuronal excitabilityinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100019en10.4067/S0716-97602006000100019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	copper zinc modulators channels neuronal excitability
spellingShingle	copper zinc modulators channels neuronal excitability DELGADO,RICARDO VERGARA,CECILIA WOLFF,DANIEL Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc
description	Based on indirect evidence, a role for synaptically released copper and zinc as modulators of neuronal activity has been proposed. To test this proposal directly, we studied the effect of copper, zinc, and other divalent cations on voltage-dependent currents in dissociated toad olfactory neurons and on their firing rate induced by small depolarizing currents. Divalent cations in the nanomolar range sped up the activation kinetics and increased the amplitude of the inward sodium current. In the micromolar range, they caused a dose dependent inhibition of the inward Na+ and Ca2+ currents (I Na and I Ca) and reduced de amplitude of the Ca2+-dependent K+ outward current (I Ca-K). On the other hand, the firing rate of olfactory neurons increased when exposed to nanomolar concentration of divalent cations and decreased when exposed to micromolar concentrations. This biphasic effect of divalent cations on neuronal excitability may be explained by the interaction of these ions with high and low affinity sites in voltage-gated channels. Our results support the idea that these ions are normal modulators of neuronal excitability
author	DELGADO,RICARDO VERGARA,CECILIA WOLFF,DANIEL
author_facet	DELGADO,RICARDO VERGARA,CECILIA WOLFF,DANIEL
author_sort	DELGADO,RICARDO
title	Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc
title_short	Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc
title_full	Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc
title_fullStr	Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc
title_full_unstemmed	Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc
title_sort	divalent cations as modulators of neuronal excitability: emphasis on copper and zinc
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100019
work_keys_str_mv	AT delgadoricardo divalentcationsasmodulatorsofneuronalexcitabilityemphasisoncopperandzinc AT vergaracecilia divalentcationsasmodulatorsofneuronalexcitabilityemphasisoncopperandzinc AT wolffdaniel divalentcationsasmodulatorsofneuronalexcitabilityemphasisoncopperandzinc
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Divalent cations as modulators of neuronal excitability: Emphasis on copper and zinc

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