Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells

Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, which appears to be critical for synaptic plasticity, one of the cellular mechani...

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Autores principales:	MUÑOZ,PABLO, ZAVALA,GABRIELA, CASTILLO,KAREN, AGUIRRE,PABLA, HIDALGO,CECILIA, NÚÑEZ,MARCO T
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	NMDA receptor calcium iron oxidative stress MAPK/ERK hippocampal slices long-term potentiation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100021
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spelling	oai:scielo:S0716-976020060001000212006-06-30Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cellsMUÑOZ,PABLOZAVALA,GABRIELACASTILLO,KARENAGUIRRE,PABLAHIDALGO,CECILIANÚÑEZ,MARCO T NMDA receptor calcium iron oxidative stress MAPK/ERK hippocampal slices long-term potentiation Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, which appears to be critical for synaptic plasticity, one of the cellular mechanisms that underlie learning and memory. In this work, we studied the effect of iron in the activation of MAPK/ERK pathway and on Ca2+ signaling in neuronal PC12 cells. We found that iron-dependent generation of hydroxyl radicals is likely to modulate Ca2+ signaling through RyR calcium channel activation, which, in turn, activates the MAPK/ERK pathway. These findings underline the relevance of iron in normal neuronal function.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100021en10.4067/S0716-97602006000100021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	NMDA receptor calcium iron oxidative stress MAPK/ERK hippocampal slices long-term potentiation
spellingShingle	NMDA receptor calcium iron oxidative stress MAPK/ERK hippocampal slices long-term potentiation MUÑOZ,PABLO ZAVALA,GABRIELA CASTILLO,KAREN AGUIRRE,PABLA HIDALGO,CECILIA NÚÑEZ,MARCO T Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
description	Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, which appears to be critical for synaptic plasticity, one of the cellular mechanisms that underlie learning and memory. In this work, we studied the effect of iron in the activation of MAPK/ERK pathway and on Ca2+ signaling in neuronal PC12 cells. We found that iron-dependent generation of hydroxyl radicals is likely to modulate Ca2+ signaling through RyR calcium channel activation, which, in turn, activates the MAPK/ERK pathway. These findings underline the relevance of iron in normal neuronal function.
author	MUÑOZ,PABLO ZAVALA,GABRIELA CASTILLO,KAREN AGUIRRE,PABLA HIDALGO,CECILIA NÚÑEZ,MARCO T
author_facet	MUÑOZ,PABLO ZAVALA,GABRIELA CASTILLO,KAREN AGUIRRE,PABLA HIDALGO,CECILIA NÚÑEZ,MARCO T
author_sort	MUÑOZ,PABLO
title	Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
title_short	Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
title_full	Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
title_fullStr	Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
title_full_unstemmed	Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
title_sort	effect of iron on the activation of the mapk/erk pathway in pc12 neuroblastoma cells
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100021
work_keys_str_mv	AT munozpablo effectofironontheactivationofthemapkerkpathwayinpc12neuroblastomacells AT zavalagabriela effectofironontheactivationofthemapkerkpathwayinpc12neuroblastomacells AT castillokaren effectofironontheactivationofthemapkerkpathwayinpc12neuroblastomacells AT aguirrepabla effectofironontheactivationofthemapkerkpathwayinpc12neuroblastomacells AT hidalgocecilia effectofironontheactivationofthemapkerkpathwayinpc12neuroblastomacells AT nunezmarcot effectofironontheactivationofthemapkerkpathwayinpc12neuroblastomacells
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Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells

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