Pituitary cell type-specific electrical activity, calcium signaling and secretion

All secretory anterior pituitary cells exhibit spontaneous and extracellular calcium-dependent electrical activity, but differ with respect to the patterns of firing and associated calcium signaling and hormone secretion. Thus, somatotrophs and lactotrophs fire plateau-bursting action potentials spo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	STOJILKOVIC,STANKO S
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	somatotrophs lactotrophs gonadotrophs GH3 cells SK channels BK channels action potentials exocytosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300004
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602006000300004
record_format	dspace
spelling	oai:scielo:S0716-976020060003000042014-01-24Pituitary cell type-specific electrical activity, calcium signaling and secretionSTOJILKOVIC,STANKO S somatotrophs lactotrophs gonadotrophs GH3 cells SK channels BK channels action potentials exocytosis All secretory anterior pituitary cells exhibit spontaneous and extracellular calcium-dependent electrical activity, but differ with respect to the patterns of firing and associated calcium signaling and hormone secretion. Thus, somatotrophs and lactotrophs fire plateau-bursting action potentials spontaneously and without coupling to calcium release from intracellular stores, which generate calcium signals of sufficient amplitude to keep steady hormone release. In these cells, both spontaneous electrical activity and basal hormone secretion can be further amplified by activation of Gq/11 and Gs-coupled receptors and inhibited by Gi/o/z-coupled receptors. In contrast, gonadotrophs fire single, high-amplitude spikes with limited ability to promote calcium influx and exocytosis, whereas activated Gq/11-coupled receptors in these cells transform single-action potential spiking into the plateau-bursting type of electrical activity and trigger periodic high-amplitude calcium signals and exocytosis of prestored secretory vesicles. Here, we review biochemical and biophysical aspects of spontaneous and receptor-controlled electrical activity, calcium signaling, and hormone secretion in pituitary cells.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.3 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300004en10.4067/S0716-97602006000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	somatotrophs lactotrophs gonadotrophs GH3 cells SK channels BK channels action potentials exocytosis
spellingShingle	somatotrophs lactotrophs gonadotrophs GH3 cells SK channels BK channels action potentials exocytosis STOJILKOVIC,STANKO S Pituitary cell type-specific electrical activity, calcium signaling and secretion
description	All secretory anterior pituitary cells exhibit spontaneous and extracellular calcium-dependent electrical activity, but differ with respect to the patterns of firing and associated calcium signaling and hormone secretion. Thus, somatotrophs and lactotrophs fire plateau-bursting action potentials spontaneously and without coupling to calcium release from intracellular stores, which generate calcium signals of sufficient amplitude to keep steady hormone release. In these cells, both spontaneous electrical activity and basal hormone secretion can be further amplified by activation of Gq/11 and Gs-coupled receptors and inhibited by Gi/o/z-coupled receptors. In contrast, gonadotrophs fire single, high-amplitude spikes with limited ability to promote calcium influx and exocytosis, whereas activated Gq/11-coupled receptors in these cells transform single-action potential spiking into the plateau-bursting type of electrical activity and trigger periodic high-amplitude calcium signals and exocytosis of prestored secretory vesicles. Here, we review biochemical and biophysical aspects of spontaneous and receptor-controlled electrical activity, calcium signaling, and hormone secretion in pituitary cells.
author	STOJILKOVIC,STANKO S
author_facet	STOJILKOVIC,STANKO S
author_sort	STOJILKOVIC,STANKO S
title	Pituitary cell type-specific electrical activity, calcium signaling and secretion
title_short	Pituitary cell type-specific electrical activity, calcium signaling and secretion
title_full	Pituitary cell type-specific electrical activity, calcium signaling and secretion
title_fullStr	Pituitary cell type-specific electrical activity, calcium signaling and secretion
title_full_unstemmed	Pituitary cell type-specific electrical activity, calcium signaling and secretion
title_sort	pituitary cell type-specific electrical activity, calcium signaling and secretion
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300004
work_keys_str_mv	AT stojilkovicstankos pituitarycelltypespecificelectricalactivitycalciumsignalingandsecretion
_version_	1718441404397518848

Pituitary cell type-specific electrical activity, calcium signaling and secretion

Ejemplares similares