Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings

The Maxi-chloride channel was the first ion channel described by electrophysiological methods in placenta. Because it is difficult to access a complex epithelium such as the placenta for electrophysiological procedures, the studies of ion channels from placental membranes have been performed only ve...

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Autor principal:	RIQUELME,GLORIA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	apical membrane chloride channel human placenta
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300006
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spelling	oai:scielo:S0716-976020060003000062014-01-24Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordingsRIQUELME,GLORIA apical membrane chloride channel human placenta The Maxi-chloride channel was the first ion channel described by electrophysiological methods in placenta. Because it is difficult to access a complex epithelium such as the placenta for electrophysiological procedures, the studies of ion channels from placental membranes have been performed only very recently. It was only in 1993 that a direct demonstration of a high-conductance chloride channel in apical membranes of intact trophoblastic epithelium was mentioned, and two years later, the description of this channel was reported from purified placental apical membranes reconstituted into artificial lipid membranes suitable for patch-clamp recordings. This brief review comments on the work done with regard to the electrophysiological characterization and regulation of the large-conductance or "Maxi" chloride channel and its contribution to the development of a cellular model for syncytiotrophoblast ion transport.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.3 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300006en10.4067/S0716-97602006000300006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	apical membrane chloride channel human placenta
spellingShingle	apical membrane chloride channel human placenta RIQUELME,GLORIA Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings
description	The Maxi-chloride channel was the first ion channel described by electrophysiological methods in placenta. Because it is difficult to access a complex epithelium such as the placenta for electrophysiological procedures, the studies of ion channels from placental membranes have been performed only very recently. It was only in 1993 that a direct demonstration of a high-conductance chloride channel in apical membranes of intact trophoblastic epithelium was mentioned, and two years later, the description of this channel was reported from purified placental apical membranes reconstituted into artificial lipid membranes suitable for patch-clamp recordings. This brief review comments on the work done with regard to the electrophysiological characterization and regulation of the large-conductance or "Maxi" chloride channel and its contribution to the development of a cellular model for syncytiotrophoblast ion transport.
author	RIQUELME,GLORIA
author_facet	RIQUELME,GLORIA
author_sort	RIQUELME,GLORIA
title	Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings
title_short	Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings
title_full	Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings
title_fullStr	Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings
title_full_unstemmed	Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings
title_sort	apical maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300006
work_keys_str_mv	AT riquelmegloria apicalmaxichloridechannelfromhumanplacenta12yearsafterthefirstelectrophysiologicalrecordings
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Apical Maxi-chloride channel from human placenta: 12 years after the first electrophysiological recordings

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